Potential Anticancer Effects of Aged Garlic Extract and its Water-soluble Organosulfur Compounds

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dc.contributor.authorAlkreathy, Huda Mohammeden_US
dc.date.accessioned2020-11-18T10:30:14Z
dc.date.available2020-11-18T10:30:14Z
dc.date.issued2020-07
dc.description.abstractBackground: Cancer is among the leading causes of morbidity and mortality globally; it often leads to a steep rise in healthcare expenses. It is a known fact that various dietary ingredients such as aged garlic is an active anticancer agent, and its extracts do not have a strong odor and pungent taste. Purpose: This review summarizes the potential beneficial effects of aged garlic extract (AGE) and its water-soluble organosulfur compounds on the cancer incidences, and in the prevention and improvement of malignancy factors. Methods: The study utilizes systematic reviews on publications of previous studies obtained from scholarly journal databases including PubMed, Medline, Ebsco Host, Google Scholar and Cochrane. The study utilizes secondary information based on the studies conducted in cancer cell lines, animal and humans as there are increasing evidence of the efficacy of AGE and AGE-derived water-soluble organosulfur compounds in cancer and other malignancies. Conclusion and Recommendation: Although animal and laboratory results were mostly consistent, there is variable evidence from human studies. The overall findings suggest that consumption of AGE and AGE-derived organosulfur compounds can offer significant protection against cancer. In our review, we found that there are shortcomings in various studies. Therefore, we recommend that more investigations are necessary to establish whether aged garlic extract could be considered for cancer preventionen_US
dc.identifier.affiliationsDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiaen_US
dc.identifier.citationAlkreathy Huda Mohammed. Potential Anticancer Effects of Aged Garlic Extract and its Water-soluble Organosulfur Compounds. Journal of Pharmaceutical Research International. 2020 Jul; 32(12): 108-121en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215819
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber12en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i1230568en_US
dc.subjectGarlicen_US
dc.subjectorganosuphuren_US
dc.subjectcanceren_US
dc.subjecttumouren_US
dc.subjectmalignancyen_US
dc.subjectanticanceren_US
dc.titlePotential Anticancer Effects of Aged Garlic Extract and its Water-soluble Organosulfur Compoundsen_US
dc.typeJournal Articleen_US
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