Production and optimization studies of cephalosporin C by solid state fermentation.

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dc.contributor.authorEllaiah, Pen_US
dc.contributor.authorPremkumar, Jen_US
dc.contributor.authorKanthachari, P V Len_US
dc.contributor.authorAdinarayana, Ken_US
dc.date.accessioned2002-02-06en_US
dc.date.accessioned2009-05-27T04:14:37Z
dc.date.available2002-02-06en_US
dc.date.available2009-05-27T04:14:37Z
dc.date.issued2002-02-06en_US
dc.description.abstractProduction of cephalosporin C employing a strain, Cephalosporium sp. NCIM 1039 under solid state fermentation was optimized. Different substrates like wheat bran, wheat grains, rice grains, barley and rice bran were studied to optimize the best substrate. Wheat bran showed the highest antibiotic yield. The physical and chemical parameters were optimized. The maximum productivity of cephalosporin C (750 U/g) was achieved by employing wheat bran and with optimized nutritional and process parameters such as potato starch as additive 1% w/w, urea as additive 1% w/w, incubation period of 7 days, incubation temperature at 30 degrees C, inoculum level 10% w/v, moisture content of solid substrate 80% and pH 7.0.en_US
dc.description.affiliationPharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India. adikunamneni@rediffmail.comen_US
dc.identifier.citationEllaiah P, Premkumar J, Kanthachari PV, Adinarayana K. Production and optimization studies of cephalosporin C by solid state fermentation. Hindustan Antibiotics Bulletin. 2002 Feb-Nov; 44(1-4): 1-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/2315
dc.language.isoengen_US
dc.subject.meshAcremonium --metabolismen_US
dc.subject.meshCephalosporins --biosynthesisen_US
dc.subject.meshCulture Mediaen_US
dc.subject.meshFermentationen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.titleProduction and optimization studies of cephalosporin C by solid state fermentation.en_US
dc.typeJournal Articleen_US
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