Antiulcer activity of Andrographis paniculata (Burm.f.) Wall. against cysteamine-induced duodenal ulcer in rats.

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dc.contributor.authorSaranya, P
dc.contributor.authorGeetha, A
dc.date.accessioned2013-02-15T08:39:47Z
dc.date.available2013-02-15T08:39:47Z
dc.date.issued2011-07
dc.description.abstractAntiulcer activity of Andrographis paniculata was evaluated by cysteamine induced duodenal ulcer model in rats. Male albino Wistar rats were pre-administered with 200 mg/kg body wt. of hydroalcoholic extact of Andrographis paniculata (HAEAP) orally, for 30 days prior to i.p. administration of 420 mg/kg body wt. of cysteamine as a single dose. Rats pre-administered with 30 mg/kg body wt. of ranitidine served as standard drug. Ulcer index, thiobarbituric acid reactive substances, mucin, glutathione peroxidase and myeloperoxidase activities, reduced glutathione/oxidized glutathione (GSH/GSSG) ratio, glycoproteins and membrane bound enzyme activities were measured in duodenum of experimental animals. The ulcer score and myeloperoxidase activity were significantly minimized in rats treated with HAEAP. Mucin content was found to be preserved in rats treated with the extract. GSH/GSSG ratio and glutathione peroxidase activities were found to be maintained by the HAEAP. Level of lipid peroxidation products was found to be significantly low in HAEAP treated rats compared to ulcer control rats. The basolateral and brush border membrane bound enzyme activities which were depleted significantly in ulcer control rats were found to be maintained in rats pre-treated with the extract. The ulcer preventing effect was comparable to that of ranitidine treated rats. Level of glycoproteins was also found to be preserved in rats treated with the extract. The normal rats treated with the HAEAP did not show any abnormal alterations in the parameters studied. Histopathological observations also showed the ulcer preventing effect of the HAEAP. It is suggested that the ulcer preventing effect may be due to its mucin preserving and antioxidant nature.en_US
dc.identifier.citationSaranya P, Geetha A. Antiulcer activity of Andrographis paniculata (Burm.f.) Wall. against cysteamine-induced duodenal ulcer in rats. Indian Journal of Experimental Biology. 2011 July; 49(7): 525-533.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145157
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/12052en_US
dc.subjectAndrographis paniculataen_US
dc.subjectBasolateral membraneen_US
dc.subjectBrushborder membraneen_US
dc.subjectCysteamineen_US
dc.subjectDuodenal ulceren_US
dc.subjectMucinen_US
dc.titleAntiulcer activity of Andrographis paniculata (Burm.f.) Wall. against cysteamine-induced duodenal ulcer in rats.en_US
dc.typeArticleen_US
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