Protective Effect of Environmental Enrichment on the Morphology of Neurons in the Motor Cortex of Diabetic and Stressed Rats

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dc.contributor.authorPamidi, Narendraen_US
dc.contributor.authorChristina, Gertrude Yapen_US
dc.contributor.authorSatheesha, Nayak Ben_US
dc.date.accessioned2020-04-23T07:26:19Z
dc.date.available2020-04-23T07:26:19Z
dc.date.issued2019-12
dc.description.abstractBackground:The present study aimed to evaluate the effects of EE on the morphology of pyramidal neuron at the motor cortex of diabetic and stressed rats.Methods and materials:Male Wistar rats were grouped into Normal Control (NC), Vehicle Control (VC), Diabetes (D), Diabetes + Stress (D+S), Diabetes + Environmental Enrichment (D+EE) and Diabetes + Stress +Environmental Enrichment (D+S+EE) (n=8). Hyperglycemia was induced in Westar rats using streptozotocin (40mg/kg; ip). Blood sugar levels and body weight was measured at regular intervals to monitor the development of hyperglycemia. All experimental groups were housed in standard cages throughout the experiment. Rats in groups D+S and D+S+EE were transferred into space restrained cages for 6 hours daily. D+S+EE group were transferred into EE cages immediately after the space restrained session for subsequent 6 hours daily. On day 30, all rats were sacrificed and brains were harvested and prepared for rapid Golgi staining protocol. Dendritic branchings and dendriticintersections of the motor cortex neurons were quantitated using a camera lucida attached to Biolux research microscope. Data was analyzed using ANOVA with Bonferroni’s test.en_US
dc.identifier.affiliationsJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Kuala Lumpur, Malaysiaen_US
dc.identifier.affiliationsDepartment of Anatomy, Melaka Manipal Medical College, Manipal University, Manipal, Karnataka, Indiaen_US
dc.identifier.citationPamidi Narendra, Christina Gertrude Yap, Satheesha Nayak B. Protective Effect of Environmental Enrichment on the Morphology of Neurons in the Motor Cortex of Diabetic and Stressed Rats. International Journal of Applied Biology and Pharmaceutical Technology. 2019 Dec; 10(4): 52-70en_US
dc.identifier.issn0976-4550
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198219
dc.languageenen_US
dc.publisherInternational Journal of Applied Biology and Pharmaceutical Technologyen_US
dc.relation.issuenumber4en_US
dc.relation.volume10en_US
dc.source.urihttps://www.doi.org/10.26502/abmb.008en_US
dc.subjectDiabetesen_US
dc.subjectStressen_US
dc.subjectMotor cortexen_US
dc.subjectNeuronsen_US
dc.subjectDendritic branchingen_US
dc.subjectEnriched environmenten_US
dc.titleProtective Effect of Environmental Enrichment on the Morphology of Neurons in the Motor Cortex of Diabetic and Stressed Ratsen_US
dc.typeJournal Articleen_US
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