Evaluation of tolerability and efficacy of glucosamine with chondroitin in the treatment of knee osteoarthritis – a double blind multicentre randomized prospective comparative study.
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Date
2011-04
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Abstract
There are few comparative studies conducted with glucosamine [GlcN1 (glucosamine
sulfate with potassium chloride), GlcN2 (glucosamine sulfate plus chondroitin sulfate) along with
ChoN3 (chondroitin sulfate alone)] in the treatment of knee osteoarthritis. In this study the treated
groups were studied for alleviation of pain and joint stiffness with correlation of measurement of
urinary pyridinium cross links such as pyridinoline (Pyr) and deoxypyridinoline (Dpyr). Hence, this
study was eventually planned to evaluate the efficacy, safety and tolerability of glucosamine with
chondroitin sulfate treated groups. Urinary pyridinium crosslinks such as Pyr and Dpyr measurement
are used to monitor the clinical status as well as bone turnover of OA patients. These two collagen
crosslinks measured in urine, which provides information both on the pathogenesis of OA as well as
the rate of bone turnover. The results of this study suggest that GlcN2 and ChoN3 can relieve pain,
improving functional ability and joint mobility so as to enhance the quality of life for osteoarthritis
patients.
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Keywords
Osteoarthritis, glucosamine, chondroitin, pyridinoline, pain
Citation
Nandhakumar J, Sengottuvelu S, Kannan S, Karthikeyan D, Ravikumar V R, Narmadha S, Sivakumar T, Tyagi M G. Evaluation of tolerability and efficacy of glucosamine with chondroitin in the treatment of knee osteoarthritis – a double blind multicentre randomized prospective comparative study. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Apr-June; 2(2): 1-11.