Effect of Leaf Extract of Senna alata on Biochemical Indices of Wistar Rats Infected with Trypanosoma brucei brucei

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dc.contributor.authorKugama, M. A.en_US
dc.contributor.authorT., Teseen_US
dc.contributor.authorSabo, H.en_US
dc.contributor.authorT., Andrewen_US
dc.contributor.authorY. A., Onaolapoen_US
dc.contributor.authorO. G., Allenen_US
dc.contributor.authorA., Agboen_US
dc.contributor.authorD. W., Danjumaen_US
dc.contributor.authorA. M., Usmanen_US
dc.contributor.authorL. M., Umaren_US
dc.contributor.authorBaji, P. J.en_US
dc.date.accessioned2020-05-05T07:04:50Z
dc.date.available2020-05-05T07:04:50Z
dc.date.issued2020-02
dc.description.abstractThis study was aimed at determining the effect of leaves of Senna alata extract on biochemical indices of Wistar rats infected with Trypanosoma brucei brucei . Phytochemical screening revealed the absence of steroids in all extracts, absence of saponins in chloroform extracts and the presence of free anthraquinones only in chloroform extract. Post - infection treatment of animals stirred the emergence of parasitaemia by Day 3. Only animals receiving 200 mg/kg b.wt. of chloroform extract survived by day 16. A significant (P<0.05) decrease in ALT for groups receiving methanol (400 mg/kg b.wt.), chloroform and aqueous extracts and significant (P<0.05) increase in unconjugated bilir ubin in the group receiving methanol extract (200 mg/kg b.wt.) compared to infected not treated rats. Significant (P<0.05) decrease in potassium concentration in groups receiving methanol and chloroform, and a significant (P<0.05) increase in sodium concen tration in the group receiving 400 mg/kg b.wt. of aqueous extract compared to the infected not treated rats. These results thereby demonstrate the ameliorative potential of Senna alata leaves against T. brucei brucei .en_US
dc.identifier.affiliationsDepartment of Human African Trypanosomiasis Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.affiliationsDepartment of Vector and Parasitological Studies Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human African Trypanosomiasis Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human African Trypanosomiasis Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human African Trypanosomiasis Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.affiliationsvDepartment of Human African Trypanosomiasis Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human African Trypanosomiasis Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.affiliationsKaduna State Ministry of Health, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human African Trypanosomiasis Research, Nigerian Institute for Trypanosomiasis Research, Kaduna, Nigeriaen_US
dc.identifier.citationKugama M. A., T. Tese, Sabo H., T. Andrew, Y. A. Onaolapo, O. G. Allen, A. Agbo, D. W. Danjuma, A. M. Usman, L. M. Umar, Baji P. J.. Effect of Leaf Extract of Senna alata on Biochemical Indices of Wistar Rats Infected with Trypanosoma brucei brucei . International Journal of Biochemistry Research & Review. 2020 Feb; 29(1): 10-19en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200774
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume29en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2020/v29i130161en_US
dc.subjectTrypanosomiasisen_US
dc.subjectSenna alataen_US
dc.subjectbiochemical indicesen_US
dc.subjectparasitaemiaen_US
dc.subjectphytochemicalen_US
dc.titleEffect of Leaf Extract of Senna alata on Biochemical Indices of Wistar Rats Infected with Trypanosoma brucei bruceien_US
dc.typeJournal Articleen_US
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