Mentha piperita (Linn.) leaf extract provides protection against radiation induced chromosomal damage in bone marrow of mice.

Simple item page
dc.contributor.authorSamarth, R Men_US
dc.contributor.authorKumar, Ashoken_US
dc.date.accessioned2009-05-28T11:00:21Z
dc.date.available2009-05-28T11:00:21Z
dc.date.issued2003-03-23en_US
dc.description.abstractOral administration of M. piperita (1 g/kg body weight/day) before exposure to gamma radiation was found to be effective in protecting against the chromosomal damage in bone marrow of Swiss albino mice. Animals exposed to 8 Gy gamma radiation showed chromosomal aberrations in the form of chromatid breaks, chromosome breaks, centric rings, dicentrics, exchanges and acentric fragments. There was a significant increase in the frequency of aberrant cells at 6 hr after irradiation. Maximum aberrant cells were observed at 12 hr post-irradiation autopsy time. Further, the frequency of aberrant cells showed decline at late post-irradiation autopsy time. However, in the animals pretreated with Mentha extract, there was a significant decrease in the frequency of aberrant cells as compared to the irradiated control. Also significant increase in percentage of chromatid breaks, chromosome breaks, centric rings, dicentrics, exchanges, acentric fragments, total aberrations and aberrations/damaged cell was observed at 12 hr post-irradiation autopsy time in control animals, whereas Mentha pretreated irradiated animals showed a significant decrease in percentage of such aberrations. A significant decrease in GSH content and increase in LPO level was observed in control animals, whereas Mentha pretreated irradiated animals exhibited a significant increase in GSH content and decrease in LPO level but the values remained below the normal. The radioprotective effect of Mentha was also demonstrated by determining the LD(50/30) values (DRF = 1.78). The results from the present study suggest that Mentha pretreatment provides protection against radiation induced chromosomal damage in bone marrow of Swiss albino mice.en_US
dc.description.affiliationRadiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, India. mamsjpr@hotmail.comen_US
dc.identifier.citationSamarth RM, Kumar A. Mentha piperita (Linn.) leaf extract provides protection against radiation induced chromosomal damage in bone marrow of mice. Indian Journal of Experimental Biology. 2003 Mar; 41(3): 229-37en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56105
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Marrow --drug effectsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshGamma Raysen_US
dc.subject.meshMaleen_US
dc.subject.meshMentha piperita --chemistryen_US
dc.subject.meshMiceen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlant Leaves --chemistryen_US
dc.titleMentha piperita (Linn.) leaf extract provides protection against radiation induced chromosomal damage in bone marrow of mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology