Anti-ulcer and antioxidant activity of Normacid, a herbomineral formulation.

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dc.contributor.authorBafna, P Aen_US
dc.contributor.authorBalaraman, Ren_US
dc.date.accessioned2009-05-28T16:08:21Z
dc.date.available2009-05-28T16:08:21Z
dc.date.issued2004-07-02en_US
dc.description.abstractEffect of various doses (125, 250, 500 and 1000 mg/kg, po) of Normacid was studied on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol-induced gastric mucosal injury in rats. The reduction in ulcer index in both the models along with the reduction in total acidity and an increase in the pH of gastric fluid in pylorus-ligated rats proved the anti-ulcer activity of Normacid. The increase in the levels of superoxide dismutase, catalase, reduced glutathione and membrane bound enzymes like Ca2+ ATPase, Mg2+ ATPase and Na+K+ ATPase and decrease in lipid peroxidation in both the models showed the antioxidant activity of the formulation. Thus it can be concluded that the anti-ulcer activity shown by Normacid may be due to the modulation of defensive factors by improvenent in gastric cytoprotection and partly due to antioxidant property.en_US
dc.description.affiliationDepartment of Pharmacy, Faculty of Technology and Engineering, MS University of Baroda, Baroda 390001, India.en_US
dc.identifier.citationBafna PA, Balaraman R. Anti-ulcer and antioxidant activity of Normacid, a herbomineral formulation. Indian Journal of Experimental Biology. 2004 Jul; 42(7): 674-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62856
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Ulcer Agents --pharmacologyen_US
dc.subject.meshAntioxidants --pharmacologyen_US
dc.subject.meshEthanol --adverse effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStomach Ulcer --chemically induceden_US
dc.titleAnti-ulcer and antioxidant activity of Normacid, a herbomineral formulation.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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