Homology Modeling and Docking Studies of Japanese Encephalitis Virus Proteins Like Envelope Protein and NS1 Protein.

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dc.contributor.authorGupt, Anil Kumar
dc.contributor.authorMishra, Santosh Kumar
dc.contributor.authorKumar, Priya Ranjan
dc.date.accessioned2015-12-18T09:52:54Z
dc.date.available2015-12-18T09:52:54Z
dc.date.issued2015-04
dc.description.abstractJapanese Encephalitis (JE) is a vector- borne, viral zoonosis that may affect humans. The disease periodically becomes endemic in areas such as northern India, parts of central and southern India. Japanese Encephalitis virus belongs to the mostly vector-borne flaviviriade, which are single stranded RNA viruses. The envelope glycoprotein of JE Viruses contain specific as well as cross relative, neutralizing epitopes. The objective of this research to find out the best ligand molecule each for the two drug targeting protein present in the JEV. This will be done by studying the complete structure of JEV drug targeting proteins and their interaction with their respective ligand. The envelope protein and NS1 protein have been studied. The minimum energies were recorded after the docking studies for all the inhibitors docked with the protein. After comparison of the minimum energies recorded, the ligand with the least minimum docking energy has been considered as the best ligand. The entire study indicates that the inhibitor Mycophenolate with minimum energy -5.00605kj/mol is the most effective against Envelope protein. However in case of NS1 protein, the inhibitor Deoxynojirimycin with the minimum energy of - 6.75932kj/mol is found to be the most effective.en_US
dc.identifier.citationGupt Anil Kumar, Mishra Santosh Kumar, Kumar Priya Ranjan. Homology Modeling and Docking Studies of Japanese Encephalitis Virus Proteins Like Envelope Protein and NS1 Protein. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Apr-June; 6(2): 126-131.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/168508
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?fid=1154en_US
dc.subjectEnvelope proteinen_US
dc.subjectNS1 proteinen_US
dc.subjectMolecular Dockingen_US
dc.subjectJapanese Encephalitis Virusen_US
dc.subjectHomology modellingen_US
dc.titleHomology Modeling and Docking Studies of Japanese Encephalitis Virus Proteins Like Envelope Protein and NS1 Protein.en_US
dc.typeArticleen_US
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