Therapeutic alternatives for the treatment of ocular toxoplasmosis

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dc.contributor.authorTavares, Harley Da Silvaen_US
dc.contributor.authorSilva, Gisele Rodrigues Daen_US
dc.date.accessioned2020-10-16T08:56:45Z
dc.date.available2020-10-16T08:56:45Z
dc.date.issued2020-09
dc.description.abstractOcular toxoplasmosis is caused by Toxoplasma gondii, inducing retinochoroiditis. It is the leading cause of infectiousposterior uveitis worldwide. Its treatment is based on oral drug administration. However, the blood–ocular barriersystems make the penetration of therapeutic drug concentrations within the eye difficult, limiting the effectiveness oftreatments. In this context, ocular drug delivery systems represent therapeutic alternative for the treatment of oculartoxoplasmosis. In this study, a review of clinical manifestations, diagnosis, treatment, and perspectives regardingthe treatment of ocular toxoplasmosis was conducted. A search was carried out on ScienceDirect, Scopus, Webof Science, PubMed, and SciELO, and the following keywords were used: toxoplasmosis, ocular toxoplasmosis,toxoplasmic retinochoroiditis, and congenital toxoplasmosis; and Boolean operators, associated with other keywords,such as epidemiology, ocular toxoplasmosis diagnosis, ocular toxoplasmosis treatment, and ocular toxoplasmosisperspectives, were applied. In conclusion, ocular toxoplasmosis still lacks effective treatment. Therefore, it is essentialto develop new molecules and/or new drug delivery systems capable of releasing therapeutic doses of anti-Toxoplasmadrugs directly in the posterior segment of the eye, for an extended period, since complications resulting from thedisease may shorten the productive life of individuals and may even lead to blindnessen_US
dc.identifier.affiliationsBiotechnology Department, Federal University of São João del-Rei, Divinópolis, Brazil.en_US
dc.identifier.affiliationsSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Brazil.en_US
dc.identifier.citationTavares Harley Da Silva, Silva Gisele Rodrigues Da. Therapeutic alternatives for the treatment of ocular toxoplasmosis. Journal of Applied Pharmaceutical Science. 2020 Sep; 2020 Sep: 140-149en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210674
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber9en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10917en_US
dc.subjectToxoplasmosisen_US
dc.subjectocular toxoplasmosisen_US
dc.subjecttoxoplasmic retinochoroiditisen_US
dc.subjectocular drug delivery systemsen_US
dc.subjectocular implantsen_US
dc.titleTherapeutic alternatives for the treatment of ocular toxoplasmosisen_US
dc.typeJournal Articleen_US
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