Therapeutic alternatives for the treatment of ocular toxoplasmosis
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Date
2020-09
Journal Title
Journal ISSN
Volume Title
Publisher
Open Science Publishers LLP
Abstract
Ocular toxoplasmosis is caused by Toxoplasma gondii, inducing retinochoroiditis. It is the leading cause of infectiousposterior uveitis worldwide. Its treatment is based on oral drug administration. However, the blood–ocular barriersystems make the penetration of therapeutic drug concentrations within the eye difficult, limiting the effectiveness oftreatments. In this context, ocular drug delivery systems represent therapeutic alternative for the treatment of oculartoxoplasmosis. In this study, a review of clinical manifestations, diagnosis, treatment, and perspectives regardingthe treatment of ocular toxoplasmosis was conducted. A search was carried out on ScienceDirect, Scopus, Webof Science, PubMed, and SciELO, and the following keywords were used: toxoplasmosis, ocular toxoplasmosis,toxoplasmic retinochoroiditis, and congenital toxoplasmosis; and Boolean operators, associated with other keywords,such as epidemiology, ocular toxoplasmosis diagnosis, ocular toxoplasmosis treatment, and ocular toxoplasmosisperspectives, were applied. In conclusion, ocular toxoplasmosis still lacks effective treatment. Therefore, it is essentialto develop new molecules and/or new drug delivery systems capable of releasing therapeutic doses of anti-Toxoplasmadrugs directly in the posterior segment of the eye, for an extended period, since complications resulting from thedisease may shorten the productive life of individuals and may even lead to blindness
Description
Keywords
Toxoplasmosis, ocular toxoplasmosis, toxoplasmic retinochoroiditis, ocular drug delivery systems, ocular implants
Citation
Tavares Harley Da Silva, Silva Gisele Rodrigues Da. Therapeutic alternatives for the treatment of ocular toxoplasmosis. Journal of Applied Pharmaceutical Science. 2020 Sep; 2020 Sep: 140-149