Erythrocyte superoxide dismutase and catalase activities and serum uric acid in patients with malignant lymphoma.

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dc.contributor.authorAreekul, Suvit
dc.contributor.authorTanthasawat, Veraporn
dc.contributor.authorPatanamatum, Suporn
dc.contributor.authorHathirat, Phongjan
dc.contributor.authorPiankijagum, Anong
dc.date.accessioned2012-05-11T07:30:50Z
dc.date.available2012-05-11T07:30:50Z
dc.date.issued1988-10
dc.description.abstractMany previous studies on superoxide dismutase (SOD) and catalase activities in red cells of patients with malignant lymphoma showed results. One possible factor may be the different oxidant stress in these patients. The objective of the present study was determine SOD and catalase activities in red cells of patients with untreated malignant lymphoma who had normal serum uric acid level. The studies were performed on 19 patients with Hodgkin's disease and 34 with non-Hodgkin's lymphoma (NHL) in comparison to 40 healthy normal subjects. The mean values of erythrocyte SOD activity in these patients were not significantly different from that of normal subjects. Serum uric acid levels were also within the normal ranges and only 4 out of 53 patients had serum uric acid over 7 mg/dl. There was no relationship between serum uric acid level would have red cell SOD within the normal limits. As hyperuricaemia may occur as a result of increased purine turnover from the increased destruction of tumor cells by therapy. The overproduction of uric acid would stimulate the generation of superoxide radicals. In such cases, red cell SOD would therefore be decreased during the hyperuicaemia. These findings may therefore explain why some previous authors found either increased or decreased SOD activity in red cell of patients with malignant lymphoma. No significant differentce of erythrocyte catalase activity between the groups of patients and the normal group was demonstrated in the present study.en_US
dc.identifier.citationAreekul Suvit, Tanthasawat Veraporn, Patanamatum Suporn, Hathirat Phongjan, Piankijagum Anong. Erythrocyte superoxide dismutase and catalase activities and serum uric acid in patients with malignant lymphoma. Siriraj Medical Journal, 1988 Oct; 40(10): 719-723.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138324
dc.language.isoenen_US
dc.source.urihttps://www.sirirajmedj.com/content_download.php?content_id=2133en_US
dc.subjectErythrocyte Superoxide Dismutaseen_US
dc.subjectCatalase Activitiesen_US
dc.subjectSerum Uric Aciden_US
dc.subjectMalignant Lymphomaen_US
dc.titleErythrocyte superoxide dismutase and catalase activities and serum uric acid in patients with malignant lymphoma.en_US
dc.typeArticleen_US
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