Induction of apoptosis by ionizing radiation in Chinese hamster V79 cells and a radioresistant cell strain derived from V79.

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dc.contributor.authorGhosh, Ren_US
dc.contributor.authorSengupta, Sen_US
dc.contributor.authorBhattacharyya, N Pen_US
dc.date.accessioned2009-05-28T14:08:01Z
dc.date.available2009-05-28T14:08:01Z
dc.date.issued1996-09-01en_US
dc.description.abstractDNA fragmentation into nucleosome ladder, a hall mark of apoptosis, could be obtained by as low as 0.58 Gy of gamma irradiation within 6 hr of irradiation which increased appreciably after 48 hr in V79 cells. In the same condition condensation of the nucleus and marginalization of the cytoplasm the characteristic morphology of apoptotic death were observed. Unirradiated controls had approximately 2% apoptotic cells. When cells were irradiated with 0.58 Gy, approximately 10% of the cells had the apoptotic morphology. This number increased to approximately 29% at 3.5 Gy dose. At a higher dose, apoptotic and necrotic cells were visualized. In radio resistant cells higher doses were required to induce morphological changes. The results indicated that gamma irradiation can induce apoptosis in Chinese hamster V79, fibroblast cell line and the radioresistant cell strain derived from V79 cells is also resistant to induction of apoptosis.en_US
dc.description.affiliationCrystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Bidhan Nagar, Calcutta, India.en_US
dc.identifier.citationGhosh R, Sengupta S, Bhattacharyya NP. Induction of apoptosis by ionizing radiation in Chinese hamster V79 cells and a radioresistant cell strain derived from V79. Indian Journal of Experimental Biology. 1996 Sep; 34(9): 863-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60313
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis --radiation effectsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshCricetulusen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshRadiation Toleranceen_US
dc.titleInduction of apoptosis by ionizing radiation in Chinese hamster V79 cells and a radioresistant cell strain derived from V79.en_US
dc.typeJournal Articleen_US
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