Effects of selenium toxicity on oestrous cyclicity, ovarian follicles, ovulation and foetal survival in rats.

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dc.contributor.authorParshad, R Ken_US
dc.date.accessioned2009-05-28T13:08:35Z
dc.date.available2009-05-28T13:08:35Z
dc.date.issued1999-06-21en_US
dc.description.abstractEffects of intraperitoneal injections of sodium selenite (2.0 and 4.0 mg/kg body weight) to normally cycling female albino Wistar rats daily for 30 days, and of single injection either during proestrous or oestrous and at each stage of the 4-day oestrous cycle were determined on oestrous cyclicity, ovarian follicles, ovulation, implantation and pregnancy outcome on day 14 of gestation. Administration of selenite for 30 days had no effect on the duration of first two oestrous cycles but afterwards the rats remained at the dioestrus stage. Their ovaries developed cystic follicles. Selenite treatments during the oestrous cycle preceding mating affects the implantation and pregnancy outcome in a dose-related manner. Its single dose containing 2.0 mg/kg body weight administered either at proestrous or oestrous, though had no effect on different reproductive parameters investigated in this study but its daily dose during the 4 day oestrous cycle reduced the number of corpora lutea and implantations as compared to saline injected control female rats. Similar effects of a single dose of selenite (4.0 mg/kg body weight) when injected at proestrous were recorded. Higher dose of selenite at oestrous or throughout the cycle decreased the number of implantations, but in addition, also increased the resorption rate/litter on day 14 of gestation. The present studies clearly show that high selenium levels in the body during the oestrous cycle preceding mating affects the number of ovulations, implantations and live embryos depending upon its dose and stage of administration.en_US
dc.description.affiliationDepartment of Zoology, Punjab Agricultural University, Ludhiana, India.en_US
dc.identifier.citationParshad RK. Effects of selenium toxicity on oestrous cyclicity, ovarian follicles, ovulation and foetal survival in rats. Indian Journal of Experimental Biology. 1999 Jun; 37(6): 615-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59018
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEstrus --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetus --drug effectsen_US
dc.subject.meshOvarian Follicle --drug effectsen_US
dc.subject.meshOvulation --drug effectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSelenium --toxicityen_US
dc.titleEffects of selenium toxicity on oestrous cyclicity, ovarian follicles, ovulation and foetal survival in rats.en_US
dc.typeJournal Articleen_US
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