Synthesis and biological evaluation of new 4-bromo-3, 5-diaryl-1-phenyl-2-pyrazoline derivatives as antioxidant and anti-inflammatory agents.
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Date
2013-02
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Abstract
A number of substituted 1, 3-diphenylprop-2-en-1-one were prepared by Claisen-Schmidt condensation of p-substituted acetophenone with o,m,psubstituted
aryl aldehydes which undergoes bromination and subsequent cyclization with phenyl hydrazine to yield 4-bromo-3(substituted phenyl)-5(substituted
phenyl)-1-phenyl-2-pyrazoline (3a-l). The structures of compounds were confirmed by elemental analysis, IR, 1HNMR and mass spectral data. The synthesized
compounds (3a-l) were screened for anti-oxidant and anti-inflammatory activity. The free radical scavenging properties were screened by using ascorbic acid as
standard antioxidant. Free radical scavenging activity was evaluated using 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical. The antioxidant activity of
compound 3b was found to be the strongest. The IC50 values of the synthesized compounds ranged between 8.87 and 81.07 (μg mL-1). The anti-inflammatory
activities were evaluated by using diclofenac sodium as a standard dug. All the compounds (20mg/kg po) possess significant anti-inflammatory activity, as reflected
by their ability to provide protection (66-99%) against carragenan induced edema in rat paw. The anti-inflammatory activity of compound 3g was found to be the
highest. The safety of substituted bromo-pyrazolines is reflected by toxicity studies.
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Keywords
1, 3-diphenylprop-2-en-1-one, antioxidant activity, anti-inflammatory activity, IC50 values, elemental analysis, IR, 1HNMR and mass spectral data
Citation
Kumar Anjan, Rout Sradhasini, Sahoo Dillip Kumar, Kumar B V V Ravi. Synthesis and biological evaluation of new 4-bromo-3, 5-diaryl-1-phenyl-2-pyrazoline derivatives as antioxidant and anti-inflammatory agents. International Journal of Research and Development in Pharmacy and Life Sciences. 2013 Feb-Mar; 2(2): 349-354.