Poly (DL-lactide-co-glycolide) microparticles as carriers for antimycobacterial drug rifampicin.

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dc.contributor.authorDutt, Men_US
dc.contributor.authorKhuller, G Ken_US
dc.date.accessioned2009-05-28T10:47:25Z
dc.date.available2009-05-28T10:47:25Z
dc.date.issued2000-09-04en_US
dc.description.abstractPoly (DL-lactide-co-glycolide) polymers were investigated as carriers for the first line antitubercular drug rifampicin. Different formulations of PLG microparticles viz. porous, non porous and hardened exhibited sustained release of rifampicin up to 7 weeks in vitro. However, hardened PLG microparticles exhibited the most sustained release in vivo in different organs up to 6 weeks. In case of free rifampicin, release was detected in vivo only up to 48 hr. In addition, no hepatotoxicity was observed on a biochemical basis (levels of SGPT, ALP and total bilirubin) in comparison to control animals. Taken together, these results suggest that polymer encapsulated antitubercular drug rifampicin may serve as an ideal therapeutic approach for treatment of tuberculous infections.en_US
dc.description.affiliationDepartment of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India.en_US
dc.identifier.citationDutt M, Khuller GK. Poly (DL-lactide-co-glycolide) microparticles as carriers for antimycobacterial drug rifampicin. Indian Journal of Experimental Biology. 2000 Sep; 38(9): 887-94en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55802
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAlanine Transaminase --metabolismen_US
dc.subject.meshAlkaline Phosphatase --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibiotics, Antitubercular --pharmacokineticsen_US
dc.subject.meshBilirubin --metabolismen_US
dc.subject.meshBiocompatible Materialsen_US
dc.subject.meshDrug Carriersen_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshFemaleen_US
dc.subject.meshLactic Acid --administration & dosageen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshParticle Sizeen_US
dc.subject.meshPolyglycolic Acid --administration & dosageen_US
dc.subject.meshPolymers --administration & dosageen_US
dc.subject.meshRifampin --pharmacokineticsen_US
dc.titlePoly (DL-lactide-co-glycolide) microparticles as carriers for antimycobacterial drug rifampicin.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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