A Study on Socio-Demographic and Clinical Profile of Patients on Second Line Anti-Retroviral Therapy Registered at ART Centre in Surat City
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Date
2025-06
Journal Title
Journal ISSN
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Publisher
Medsci Publications
Abstract
Background: There is a need to develop concrete data in India about the number of people who need to switch to second-line HIV drugs and widespread emergence of drug resistance threatens the sustainability of the national programme. This study was conducted to study on Socio-Demographic and Clinical Profile of Patients on Second Line Anti-Retroviral Therapy Registered at ART Centre in Surat City. Methodology: The present study was a Cross-sectional study conducted at the ART centre of Gujarat, which are providing free second line ART. The study was conducted by pretested semi-structured questionnaire. The information regarding socio-demography and clinical variables, treatment and sexual activity were taken by oral interview of patients. While information regarding laboratory profile, adherence and treatment history were taken from patient treatment cards. Results: Most common reason for switch to second line ART was virological failure (84.2%). Mean duration of first line ART treatment was 30.15 (S.D. 25.350) months. All patients were given ritonavir boosted PI. Majority (66.7%) were given Atazinavir-ritonavir boosted PI and around 30% had history of substitution within second line ART. Conclusion: On the basis of our findings, we conclude that early detection of first-line treatment failure and improve availability/affordability of second-line regimens should become priorities in National Programme. First line ART patients with history of tuberculosis following ART initiation, treatment interruptions, treatment from private facility, belonging to nuclear family and lower social-economic class should be watched for ART failure.
Description
Keywords
Socio-Demographic Profile, Clinical Profile, Second Line Anti-Retroviral Therapy, ART Centre, HIV
Citation
Parmar G, Parmar S, Amin SS, Patel NB. A Study on Socio-Demographic and Clinical Profile of Patients on Second Line Anti-Retroviral Therapy Registered at ART Centre in Surat City. National Journal of Medical Research . 2025 Jun; 15(2): 164-169