Dendritic cells and antigen trapping technology--a revolution in vaccine/immunotherapy strategy.

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dc.contributor.authorPal, Chiranjiben_US
dc.contributor.authorGanguly, Dipyamanen_US
dc.contributor.authorPaul, Kausiken_US
dc.contributor.authorPal, Srijiben_US
dc.date.accessioned2009-05-28T16:24:21Z
dc.date.available2009-05-28T16:24:21Z
dc.date.issued2007-06-26en_US
dc.description108 references.en_US
dc.description.abstractVaccines based on dendritic cells--the immune system's key responders to foreign invaders--grabbed the spotlight of this decade. Scientists have devised a dozen different ways to make dendritic cell vaccines. They have linked dendritic cells with all kinds of antigens, including peptides derived from gene mutations, tumor/pathogen RNA, viral vectors, and with whole pathogen/tumor lysate. And they are adding cytokines such as granulocyte macrophage colony stimulating factor or interleukin 4 during dendritic cell growth or maturation or at the site of vaccination to try to boost response. We are still learning the best way to generate the dendritic cells, load them with the antigen and send them to the right place in the body, and use of the biological stage of development of dendritic cells that is best suited to stimulate a response. In the present review attempts have been made to present a comprehensive synopsis of the history, development and ramifications of evolving knowledge on dendritic cell biology and the prospects for being developed as a rational immunotherapeutic tool. Further clinical studies are warranted.en_US
dc.description.affiliationDepartment of Zoology, Brahmananda Keshab Chandra College, 111/2, B.T. Road, Bonhooghly, Kolkata 700 108, India. chiranjibpal@yahoo.co.inen_US
dc.identifier.citationPal C, Ganguly D, Paul K, Pal S. Dendritic cells and antigen trapping technology--a revolution in vaccine/immunotherapy strategy. Indian Journal of Experimental Biology. 2007 Jun; 45(6): 491-504en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63192
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5267/1/IJEB%2045%286%29%20491-504.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens --immunologyen_US
dc.subject.meshCancer Vaccines --therapeutic useen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Movementen_US
dc.subject.meshDendritic Cells --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Cellular --geneticsen_US
dc.subject.meshImmunotherapy --methodsen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshOrganisms, Genetically Modifieden_US
dc.subject.meshT-Lymphocytes --physiologyen_US
dc.subject.meshVaccination --methodsen_US
dc.subject.meshViruses --immunologyen_US
dc.titleDendritic cells and antigen trapping technology--a revolution in vaccine/immunotherapy strategy.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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