Role of Bougainvillea glabra Stem Extract on Paracetamol and Alcohol-Induced Hepatotoxicity in Rats

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dc.contributor.authorManjunath, Lakshminarayanaen_US
dc.contributor.authorJogpal, Vikasen_US
dc.date.accessioned2024-09-24T08:59:30Z
dc.date.accessioned2024-09-24T11:51:33Z
dc.date.available2024-09-24T08:59:30Z
dc.date.available2024-09-24T11:51:33Z
dc.date.issued2024-02
dc.description.abstractThe current study investigates the in-vivo hepatoprotective effectiveness of Bougainvillea glabra stem extract against alcohol and paracetamol-induced hepatotoxicity in animal models. The alterations in liver enzymes including serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), and total bilirubin are studied in rats given B. glabra extract with paracetamol or alcohol to produce hepatotoxicity. The levels of glutathione and lipid peroxidation were also examined, and the outcomes were contrasted with silymarin as the reference. The acute toxicity studies presented the plant extract under category 5 of GHS system, which further motivated the studies for hepatoprotective activity. The induction of hepatotoxicity was confirmed with the elevated levels of serum and tissue biochemical by the administration of paracetamol and alcohol. Under paracetamol as a hepatotoxin, the animals with 200 and 400 mg/kg p.o demonstrated near figures for SGPT and SGOT of the group treated with silymarin with significance. The results were still more appreciative under alcohol as a hepatotoxin. In both cases, the group with 400 mg/kg p.o gave a promising result with the reduced inflammatory cells under histopathological studies.en_US
dc.identifier.affiliationsSchool of Medical and Allied Sciences G. D. Goenka University, Sohna, Gurugram, Haryana, Indiaen_US
dc.identifier.affiliationsSchool of Medical and Allied Sciences G. D. Goenka University, Sohna, Gurugram, Haryana, Indiaen_US
dc.identifier.citationManjunath Lakshminarayana, Jogpal Vikas . Role of Bougainvillea glabra Stem Extract on Paracetamol and Alcohol-Induced Hepatotoxicity in Rats . International Journal of Pharmaceutical Sciences and Drug Research . 2024 Jan; 16(1): 1-8en_US
dc.identifier.issn0975–248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231746
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2024.160101en_US
dc.subjectBougainvillea glabra extracten_US
dc.subjectHepatoprotectiveen_US
dc.subjectParacetamolen_US
dc.subjectAlcoholen_US
dc.subjectSerum glutamic oxaloacetic transaminaseen_US
dc.subjectSerum glutamic pyruvic transaminaseen_US
dc.subjectAlkaline phosphataseen_US
dc.subjectTotal bilirubinen_US
dc.titleRole of Bougainvillea glabra Stem Extract on Paracetamol and Alcohol-Induced Hepatotoxicity in Ratsen_US
dc.typeJournal Articleen_US
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