Potential antifilarial activity of roots of Asparagus adscendens Roxb, against Setaria cervi in vitro.

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dc.contributor.authorSingh, Ren_US
dc.contributor.authorKhan, N Uen_US
dc.contributor.authorSinghal, K Cen_US
dc.date.accessioned2009-05-28T14:54:29Z
dc.date.available2009-05-28T14:54:29Z
dc.date.issued1997-02-01en_US
dc.description.abstractEffect of aqueous and alcoholic extracts of the roots of A. adscendens was studied on the spontaneous movements of whole worm and nerve muscle (n.m.) preparation of S. cervi and on the survival of microfilariae in vitro. Aqueous as well alcoholic extracts caused inhibition of spontaneous motility of whole worm and n.m. preparation of S. cervi characterized by initial, short lasting small increase in amplitude and tone of contractions followed by paralysis. The initial stimulatory effect was not observed by aqueous extract on n.m. preparation. The concentration required to inhibit the movements of n.m. preparation was 1/4th for aqueous and 1/3rd for alcoholic extract suggesting a cuticular permeability barrier. The effect of acetylcholine on n.m. preparation was concentration related being more with a concentration of 5 micrograms/ml as compared to 1 microgram/ml. Both alcoholic as well as aqueous extracts caused death of microfilariae in vitro, LC50 and LC90 being 8 and 16 ng/ml for aqueous, 3 and 12 ng/ml for alcoholic extracts respectively.en_US
dc.description.affiliationDepartment of Pharmacology, J N Medical College, Aligarh, India.en_US
dc.identifier.citationSingh R, Khan NU, Singhal KC. Potential antifilarial activity of roots of Asparagus adscendens Roxb, against Setaria cervi in vitro. Indian Journal of Experimental Biology. 1997 Feb; 35(2): 168-72en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61310
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnthelmintics --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshLiliaceae --chemistryen_US
dc.subject.meshPlant Roots --chemistryen_US
dc.subject.meshSetaria Nematode --drug effectsen_US
dc.titlePotential antifilarial activity of roots of Asparagus adscendens Roxb, against Setaria cervi in vitro.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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