The ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gastritis.

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dc.contributor.authorGoto, Yasuyukien_US
dc.contributor.authorAndo, Takafumien_US
dc.contributor.authorNishio, Kazukoen_US
dc.contributor.authorIshida, Yoshikoen_US
dc.contributor.authorKawai, Sayoen_US
dc.contributor.authorGoto, Hidemien_US
dc.contributor.authorHamajima, Nobuyukien_US
dc.date.accessioned2009-05-27T17:45:31Z
dc.date.available2009-05-27T17:45:31Z
dc.date.issued2005-10-27en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractStudies of the angiotensin converting enzyme (ACE) I/D polymorphism have provided evidence that the D/D genotype is associated with gastric tumor progression and numbers of lymph node metastases, but not with the overall risk of gastric cancer. The highest levels of circulating and tissue ACE activity were found in carriers of the D/D genotype. Here, we further investigated the association using 454 Japanese subjects undergoing a health checkup and 202 gastric cancer patients. The ACE polymorphism was not found to be linked with H. pylori seropositivity or gastric atrophy. However, among H. pylori seropositive subjects with atrophy, those with the I/D genotype had an increased risk of gastric cancer (OR=1.59; 95% CI, 1.02-2.48). We also established that the polymorphism did not lower the age at diagnosis of gastric cancer. Confirmation of the association between ACE polymorphisms and development of gastric cancer requires much larger studies, and the biological role also needs to be fully elucidated.en_US
dc.description.affiliationDepartment of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. y-goto@med.nagoya-u.ac.jpen_US
dc.identifier.citationGoto Y, Ando T, Nishio K, Ishida Y, Kawai S, Goto H, Hamajima N. The ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gastritis. Asian Pacific Journal of Cancer Prevention. 2005 Oct-Dec; 6(4): 464-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37827
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdenocarcinoma --epidemiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAntibodies, Bacterial --blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastritis, Atrophic --geneticsen_US
dc.subject.meshHelicobacter pylori --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPepsinogens --blooden_US
dc.subject.meshPeptidyl-Dipeptidase A --geneticsen_US
dc.subject.meshPolymorphism, Genetic --geneticsen_US
dc.subject.meshStomach Neoplasms --epidemiologyen_US
dc.titleThe ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gastritis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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