Salivary Cortisol Levels in Severely Depressed Patients and Healthy Individuals

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dc.contributor.authorKhan, Qudsia Umairaen_US
dc.contributor.authorKhan, Haseeb Ahmeden_US
dc.contributor.authorTauseef, Ambreenen_US
dc.contributor.authorHafeez, Faridaen_US
dc.contributor.authorQamar, Mehwishen_US
dc.contributor.authorFatima, Syeda Abeeren_US
dc.contributor.authorNadeem, Amnaen_US
dc.contributor.authorZulfiqar, Sibghaen_US
dc.date.accessioned2020-09-24T07:51:57Z
dc.date.available2020-09-24T07:51:57Z
dc.date.issued2019-05
dc.description.abstractIntroduction: This study compared the levels of salivary cortisol in patients suffering from severe depression and in healthy individuals. Methods: Sample size included 30 diagnosed cases of major depression based on outdoor clinical assessment (from April 2015 to December 2105) and was established by ICD-10 and DSM-IV criteria and 30 physically and mentally healthy subjects. In this study diagnosed cases of hyperaldosteronism, Cushing’s syndrome/ disease were omitted. A predesigned proforma was created on the basis of Becks Inventory. Saliva samples were collected and processed, and the measurement of cortisol levels was done by ELISA. Results: In a normal subject, the mean cortisol level was 1.46 ± 0.9 μg/dl (Mean ± SD) whereas in depressive patients it was raised (2.2 ± 1.6 μg/dl, p=0.031). Results also showed that high level of cortisol in saliva was found in individuals with a positive family history of depression (2.3 ± 1.8 μg/dl) as compared to healthy subjects (1.5 ± 1.0 μg/dl). Mean BMI was also found to be different between the 2 groups (p=0.012). Conclusion: We concluded that salivary cortisol may act as an early diagnostic tool and non-invasive biomarker for prompt diagnosis of potential cases of depression for effective management. Hence, early initiation of treatment can be helpful in improving the late clinical consequences in severely depressed patients and decreasing the morbidity.en_US
dc.identifier.affiliationsDepartment of Physiology, CMH Lahore Medical College, Lahore, Pakistanen_US
dc.identifier.affiliationsDepartment of Physiology, Shaikh Zayed Federal Postgraduate Medical Institute, Lahore, Pakistanen_US
dc.identifier.citationKhan Qudsia Umaira, Khan Haseeb Ahmed, Tauseef Ambreen, Hafeez Farida, Qamar Mehwish, Fatima Syeda Abeer, Nadeem Amna, Zulfiqar Sibgha. Salivary Cortisol Levels in Severely Depressed Patients and Healthy Individuals. International Journal of Medical Research & Health Sciences. 2019 May; 8(5): 21-25en_US
dc.identifier.issn2319-5886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204915
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber5en_US
dc.relation.volume8en_US
dc.source.urihttps://www.ijmrhs.com/abstract/salivary-cortisol-levels-in-severely-depressed-patients-and-healthy-individuals-18377.htmlen_US
dc.subjectDepressionen_US
dc.subjectSalivaen_US
dc.subjectCortisolen_US
dc.subjectFamily historyen_US
dc.subjectBiomarkeren_US
dc.titleSalivary Cortisol Levels in Severely Depressed Patients and Healthy Individualsen_US
dc.typeJournal Articleen_US
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