An experimental study to evaluate the role of aspirin and metformin in prevention of depression in rats

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dc.contributor.authorAbbas, Alishaen_US
dc.contributor.authorKumar, Narendraen_US
dc.contributor.authorSingh, Sarveshen_US
dc.contributor.authorKumar, Rahulen_US
dc.contributor.authorAhmad, Akhlaqueen_US
dc.contributor.authorNath, Rajendraen_US
dc.contributor.authorDixit, Rakesh Kumaren_US
dc.date.accessioned2020-04-23T08:01:41Z
dc.date.available2020-04-23T08:01:41Z
dc.date.issued2020-04
dc.description.abstractBackground: Depression was seen to be associated with an increased level of inflammatory biomarkers along with the disturbance in the monoamine neurotransmitter system. Current therapies are mostly focussed on the neurotransmitters imbalance but due to increasing cases of treatment failure there is a need to shift our treatment focus to other potential therapies. This study aimed to evaluate the preventive role of aspirin and metformin in stress induced model of depression in wistar rats.Methods: Fifty four wistar rats were randomly divided into nine groups as normal control, experimental control, aspirin (30 mg/kg, 60 mg/kg), metformin (50 mg/kg, 100 mg/kg), two combination groups and imipramine (15 mg/kg). Depression model was created by the induction of chronic unpredictable mild stress (CUMS) for consecutive 28 days. Behavioural assessment was done by evaluating immobility time in forced swim test (FST) and sucrose preference ratio (SPR) in sucrose preference test. The data were analysed by analysis of variance (ANOVA) test using SPSS software. P<0.05 was considered to be statistically significant.Results: The CUMS led to an increase in immobility time and decrease in SPR. Aspirin and Metformin alone and their combinations showed statistically significant response in preventing the immobility time to increase (p<0.001) and SPR to decrease (p<0.001). However the response of Aspirin was comparable with Imipramine but the response of Metformin was not as significant as of Imipramine (p>0.05).Conclusions: Aspirin and metformin might have a potential role in the prevention of depression.en_US
dc.identifier.affiliationsDepartment of Pharmacology, King George Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationAbbas Alisha, Kumar Narendra, Singh Sarvesh, Kumar Rahul, Ahmad Akhlaque, Nath Rajendra, Dixit Rakesh Kumar. An experimental study to evaluate the role of aspirin and metformin in prevention of depression in rats. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 605-610en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200578
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201185en_US
dc.subjectAspirinen_US
dc.subjectChronic unpredictable mild stressen_US
dc.subjectDepressionen_US
dc.subjectInflammationen_US
dc.subjectMetforminen_US
dc.titleAn experimental study to evaluate the role of aspirin and metformin in prevention of depression in ratsen_US
dc.typeJournal Articleen_US
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