Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles.

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dc.contributor.authorKhan, Shagufta
dc.contributor.authorTiwari, Tripti
dc.contributor.authorTyagi, Shweta
dc.contributor.authorBhowmik, Mithun
dc.contributor.authorJoshi, Amit
dc.contributor.authorDubey, Balkrishna
dc.date.accessioned2013-04-29T06:22:05Z
dc.date.available2013-04-29T06:22:05Z
dc.date.issued2012-10
dc.description.abstractDithranol belongs to the keratolytic category, which is widely used drug in the treatment of psoriasis. The drug is practically insoluble in water. Many conventional dosage forms for psoriasis treatment have been have been formulated earlier, but they did not show good results. Hence in the present study, it was attempted to formulate dithranol in the form of solid lipid nanoparticle. Solid lipid nanoparticles of dithranol were obtained by adaption of lipid dispersion method. Preformulation studies were performed to check the compatibility of drug and excepient for the preparation of formulation by DSC and no interaction was found. Solubility study, partition coefficient determination, UV analysis, HPLC study, FTIR study were also performed. After the preformulation studies Dithranol loaded solid lipid nanoparticles was also prepared. Hence it was concluded that solid lipid nanoparticle of dithranol could be formulated.en_US
dc.identifier.citationKhan Shagufta, Tiwari Tripti, Tyagi Shweta, Bhowmik Mithun, Joshi Amit, Dubey Balkrishna. Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles. International Journal of Research and Development in Pharmacy and Life Sciences. 2012 Oct-Nov; 1(4): 183-188.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/146391
dc.language.isoenen_US
dc.source.urihttps://www.ijrdpl.com/docs/fwd4thissueforfinalupload/3.pdfen_US
dc.subjectdithranolen_US
dc.subjectpsoriasisen_US
dc.subjectsolid lipid nanoparticleen_US
dc.subjectpreformulation studiesen_US
dc.titlePreformulations studies and preperation of dithranol loaded solid lipid nanoparticles.en_US
dc.typeArticleen_US
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