Inflammation & apoptosis in spinal cord injury.
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Date
2012-03
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Abstract
Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery.
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Keywords
Apoptosis, inflammation, mechanisms, spinal cord injury, therapy
Citation
Zhang Ning, Yin Ying, Xu Sheng-Jie, Wu Yong-Ping, Chen Wei-Shan. Inflammation & apoptosis in spinal cord injury. Indian Journal of Medical Research. 2012 Mar; 135(3): 287-296.