Effects of Magnesium Hydroxide on Disintegration Time and Dissolution Rate of Diclofenac Sodium Plain Tablet.
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Date
2007-12
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Abstract
The objective of this study was to evaluate the effects of magnesium hydroxide (MH) on disintegration
time (DT) and dissolution profile of diclofenac sodium (DS) plain tablet. The tablets of DS were
formulated with conventionally used excipients and investigational agent Mg [OH] 2. Different
parameters of tablets like hardness, thickness, friability, and disintegration time and dissolution rate
were determined to assess the effects of MH on these parameters. The physical resistance against
abrasion or shock of DS-MH tablets had been noticed by the results of hardness and friability test
which were within the limits of standard specification. The disintegration times of tablets of the
experimental batches except one, found 2.0 to 25 minutes were also within the limits of standard
specification. The release rates of DS in simulated gastric fluid (SGF) at 30 minutes were inspiring
about batches FO3: 84.78% and FO4: 90.38%. A positive correlation of coefficient determined between
quantity of Mg(OH)2 in different batches of tablets and their effects on dissolution rate was found
statistically significant (r = 0.66). The tmax of DS was not affected by the presence or increment of
MH as evident in r tmax= 0.50. The overall study indicated that Magnesium hydroxide didn’t affect
the different physical parameters of plain tablet rather it in certain quantity while present in some
batches assisted rapid disintegration and release profile of active content Diclofenac sodium. The
DS-MH plain tablet to provide rapid disintegration, dissolution and absorption hence fastest antiinflammatory
action with acid neutralizing benefits by MH, might be considered sincerely
Description
Keywords
Diclofenac Sodium, Magnesium Hydroxide, Disintegration, Dissolution
Citation
Miazi M M H, Choudhury M M A, Rahman M H, Rahman A. Effects of Magnesium Hydroxide on Disintegration Time and Dissolution Rate of Diclofenac Sodium Plain Tablet. Journal of Bangladesh Society of Physiologists. 2007 Dec; 2(1): 42-48.