Estimation of bone mineral density and its correlations with homocysteine, and various other biochemical bone markers in postmenopausal women

Simple item page
dc.contributor.authorVerma, Rajeeven_US
dc.contributor.authorKumar, Satishen_US
dc.contributor.authorAtam, Ishaen_US
dc.contributor.authorAtam, Virendraen_US
dc.contributor.authorVerma, Sudhiren_US
dc.contributor.authorSonkar, Satyendra Kumaren_US
dc.contributor.authorKumar, Ajayen_US
dc.contributor.authorChaudhary, Shyam Chanden_US
dc.date.accessioned2020-09-24T07:34:31Z
dc.date.available2020-09-24T07:34:31Z
dc.date.issued2019-10
dc.description.abstractIntroduction- Omocysteine (HCY) prevents collagen cross-linking and activates osteoclast function within the bones. Bone mineral density (BMD) may be affected by Hyperhomocysteinemia via Cathepsin K. Aim- To find the correlation of BMD with biochemical bone markers. Methods- BMD was investigated by the DXA scan with the help of the Hologic QDR1000 system. As per WHO guidelines, subjects were divided into three different subsets with; normal bone mass, osteopenia, and osteoporosis. Every subject underwent routine biochemical laboratory investigations, HCY, Vitamin B12, and folic acid levels. Results-Among 355 postmenopausal women, 69% (245) had osteoporosis while 11.27% (40) had normal BMD (mean age, 53 ± 8.35 years) and 19.72% (70) had osteopenia (mean age 52.86 ± 7.93 years). The mean age in the osteoporotic group was 56.49 ± 6.65 years. The mean levels of HCY in the three groups were 15.58± 7.92 μmol/L, 16.13± 7.34μmol/L and 17.05± 5.13μmol/L, respectively. Hip BMD showed a strong inverse correlation with age (r=-0.360, p=0.002), while no significant correlations were found between weight and BMI. PTH was consistently seen to be negatively correlated with BMD at Spine (r=-0.0339, p=0.004), Forearm (r=-0.267, p=0.027), and Hip (r=-0.224, p=0.064). Conclusion- Low BMD is an important problem in postmenopausal female patients. Age and duration of menopause are independent risk predictors for the development of osteoporosis. Vitamin D levels do not predict low BMD in postmenopausal females. Weight is protective for osteoporosis especially at spine and forearm BMD. Vitamin B12 and Hcy levels did not correlate with low BMD.en_US
dc.identifier.affiliationsDepartment of Medicine, King George’s Medical University, Lucknow, India, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrinology, King George’s Medical University, Lucknow, India, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, King George’s Medical University, Lucknow, India, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, King George’s Medical University, Lucknow, India, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, King George’s Medical University, Lucknow, India, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, King George’s Medical University, Lucknow, India, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, King George’s Medical University, Lucknow, India, Indiaen_US
dc.identifier.citationVerma Rajeev, Kumar Satish, Atam Isha, Atam Virendra, Verma Sudhir, Sonkar Satyendra Kumar, Kumar Ajay, Chaudhary Shyam Chand. Estimation of bone mineral density and its correlations with homocysteine, and various other biochemical bone markers in postmenopausal women. International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL). 2019 Oct; 8(4): 22-28en_US
dc.identifier.issn2282-0238
dc.identifier.issn2393-932X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203825
dc.languageenen_US
dc.publisherSociety for research and Development in Educationen_US
dc.relation.issuenumber4en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.21276/IJRDPL.2278-0238.2019.8(4).22-28en_US
dc.subjectBone mineral densityen_US
dc.subjectcathepsin Ken_US
dc.subjecthomocysteineen_US
dc.subjectosteoporosisen_US
dc.subjectpostmenopausalen_US
dc.titleEstimation of bone mineral density and its correlations with homocysteine, and various other biochemical bone markers in postmenopausal womenen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijrdpl2019v8n4p22.pdf
Size:
481.33 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Research and Development in Pharmacy and Life Sciences