Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application.

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dc.contributor.authorSalama, Mohamed
dc.contributor.authorMahdy, Mahmoud A
dc.contributor.authorMohamed, Amina
dc.contributor.authorMohamed, Aref T
dc.contributor.authorKeleb, Eseldin I
dc.contributor.authorOmar, Assad A
dc.contributor.authorElmarzugi, Nagib A
dc.date.accessioned2015-07-07T06:05:07Z
dc.date.available2015-07-07T06:05:07Z
dc.date.issued2015-05
dc.description.abstractThe objective of the current paper was to prepare and evaluate various polymeric films for fungal infection treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as antifungal drug were prepared by solvent casting technique. The prepared films were tested for their physicomechanical properties as tensile strength, physical endurance, elasticity, water vapor permeation and water loss. The release of ketoconazole from the prepared medicated films was examined. It is involved 20 volunteers suffering from legs fungal infection. Ten of the patients used the films and a follow up study was carried out for 14 days, in comparison with other patients who applied ketoconazole medicated ointment, cream gel and Emulgel. The results revealed that films prepared with Eudragit RL 100 containing glyceryl triacetate produced maximum release of ketoconazole both In vitro and In vivo as compared with other topical dosage forms as ointment, cream, gel and Emulgel. Moreover, the films constitute a simple and convenient method for treatment of various fungal infections. As conclusion, the use of antifungal drugs such as Ketoconazole incorporated in polymeric films, the output results provided promised evidence in the treatment of dermatophytosis.en_US
dc.identifier.citationSalama Mohamed, Mahdy Mahmoud A, Mohamed Amina, Mohamed Aref T, Keleb Eseldin I, Omar Assad A. Elmarzugi Nagib A. Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application. Journal of Applied Pharmaceutical Science. 2015 May; 5(5): 28-32.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159203
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=1504en_US
dc.subjectKetoconazoleen_US
dc.subjectEudragit RL 100en_US
dc.subjectPolymeric filmen_US
dc.subjectAntifungal drugsen_US
dc.titleFormulation and Evaluation of Ketoconazole Polymeric Films for Topical Application.en_US
dc.typeArticleen_US
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