Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application.
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Date
2015-05
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Abstract
The objective of the current paper was to prepare and evaluate various polymeric films for fungal infection
treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as
antifungal drug were prepared by solvent casting technique. The prepared films were tested for their physicomechanical
properties as tensile strength, physical endurance, elasticity, water vapor permeation and water loss.
The release of ketoconazole from the prepared medicated films was examined. It is involved 20 volunteers
suffering from legs fungal infection. Ten of the patients used the films and a follow up study was carried out for
14 days, in comparison with other patients who applied ketoconazole medicated ointment, cream gel and
Emulgel. The results revealed that films prepared with Eudragit RL 100 containing glyceryl triacetate produced
maximum release of ketoconazole both In vitro and In vivo as compared with other topical dosage forms as
ointment, cream, gel and Emulgel. Moreover, the films constitute a simple and convenient method for treatment
of various fungal infections. As conclusion, the use of antifungal drugs such as Ketoconazole incorporated in
polymeric films, the output results provided promised evidence in the treatment of dermatophytosis.
Description
Keywords
Ketoconazole, Eudragit RL 100, Polymeric film, Antifungal drugs
Citation
Salama Mohamed, Mahdy Mahmoud A, Mohamed Amina, Mohamed Aref T, Keleb Eseldin I, Omar Assad A. Elmarzugi Nagib A. Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application. Journal of Applied Pharmaceutical Science. 2015 May; 5(5): 28-32.