Lymphocytic colitis: an Important but Underdiagnosed Cause of Chronic Diarrhoea in Adult Nigerians

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dc.contributor.authorOkonkwo, Ken_US
dc.contributor.authorOjo, Oen_US
dc.contributor.authorBetiku, Oen_US
dc.date.accessioned2024-09-24T08:09:52Z
dc.date.available2024-09-24T08:09:52Z
dc.date.issued2024-06
dc.description.abstractIntroduction : Lymphocytic colitis is an important cause of chronic diarrhoea which is amenable to appropriate treatment which helps to reduce the morbidity and mortality associated with chronic diarrhoea.In Africa unfortunately, there is poor awareness of this treatable cause of chronic diarrhoea on account of a paucity of skilled experts necessary to make a diagnosis and implement effective therapy.Aim :We present the clinical aspects, endoscopic findings and Introduction :Lymphocytic colitis is an important cause of chronic diarrhoea which is amenable to appropriate treatment which helps to reduce the morbidity and mortalit y associated with chronic diarrhoea. In Africa unfortunately, there is poor awareness of this treatable cause o chronic diarrhoea on account of a paucity of skilled experts necessary to make a diagnosis and implement effective therapy. Aim : We present the clinical aspects, endoscopic findings and pathological features of twenty-one Nigerian patients with lymphocytic colitis. A short literature review of the epidemiological, clinical, endoscopic, and pathological features of this important condition is also presented. Materials and Methods : This was a retrospective analysis of the clinical, endoscopic and pathological findings of twenty-one patients who were diagnosed with lymphocytic colitis following colonoscopy in an open-access endoscopy setting in Akure, Ondo State, Nigeria over eighteen months. Results : Twenty-one diagnoses of lymphocytic colitis were made from a pool of one hundred and twenty-two colonosco pies done between December 2021 and May 2023.There were slightly more females diagnosed with an M: F ratio of 3:4 with a mean (SD) age of 52.2 (± 14.3) years. All of the patients had a history of passage of watery diarrhoea while normal colonoscopy findings were present in 87.5%. The mean (SD) time to diagnosis in five of these study subjects was 18.4 ± 9.1 months.These patients had standard medical treatment with good outcomes. Conclusion : In sub-Saharan Africa, lymphocytic diarrhoea is a treatable cause of chronic diarrhoea. It is important to refer patients with chronic diarrhoea to facilities where they can benefit from the expertise of endoscopists and pathologists. pathological features of twenty-one Nigerian patients with lymphocytic colitis.A short literature review of the epidemiological, clinical, endoscopic, and pathological features of this important condition is also presented. Materials and Methods :This was a retrospective analysis of the clinical, endoscopic and pathological findings of tIntroduction : Lymphocytic colitis is an important cause of chronic diarrhoea which is amenable to appropriate treatment which helps to reduce the morbidity and mortality associated with chronic diarrhoea. In Africa unfortunately , there is poor awareness of this treatable cause of chronic diarrhoea on account of a paucity of skilled experts necessary to make a diagnosis and implement effective therapy. Aim : We present the clinical aspects, endoscopic findings and pathological features of twenty-one Nigerian patients with lymphocytic colitis. A short literature review of the epidemiological, clinical, endoscopic, and pathological features of this important condition is also presented. Materials and Methods :This was a retrospective analysis of the clinical, endoscopic and pathological findings of twenty-one patients who were diagnosed with lymphocytic colitis following colonoscopy in an open-access endoscopy setting in Akure, Ondo State, Nigeria over eighteen months. Results :Twenty-one diagnoses of lymphocytic colitis were made from a pool of one hundred and twenty-two colonoscopies done between December 2021 and May 2023.There were slightly more females diagnosed with an M: F ratio of 3:4 with a mean (SD) age of 52.2 (± 14.3) years. All of the patients had a history of passage of watery diarrhoea while normal colonoscopy findings were present in 87.5%. The mean (SD) time to diagnosis in five of these study subjects was 18.4 ± 9.1 months. These patients had standard medical treatment with good outcomes. Conclusion : In sub-Saharan Africa, lymphocytic diarrhoea is a treatable cause of chronic diarrhoea. It is important to refer patients with chronic diarrhoea to facilities where they can benefit from the expertise of endoscopists and pathologists.wenty-one patients who were diagnosed with lymphocytic colitis following colonoscopy in an open-access endoscopy setting in Akure, Ondo State, Nigeria over eighteen months. Results :Twenty-one diagnoses of lymphocytic colitis were made from a pool of one hundred and twenty-two colonoscopies done between December 2021 and May 2023. There were slightly more females diagnosed withIntroduction : Lymphocytic colitis is an important cause of chronic diarrhoea which is amenable to appropriate treatment which helps to reduce the morbidity and mortality associated with chronic diarrhoea.In Africa unfortunately , there is poor awareness of this treatable cause of chronic diarrhoea on account of a paucity of skilled experts necessary to make a diagnosis and implement effective therapy. Aim :We present the clinical aspects, endoscopic findings and pathological features of twenty-one Nigerian patients with lymphocytic colitis. A short literature review of the epidemiological, clinical, endoscopic, and pathological features of this important condition is also presented. Materials and Methods :This was a retrospective analysis of the clinical, endoscopic and pathological findings of twenty-one patients who were diagnosed with lymphocytic colitis following colonoscopy in an open-access endoscopy setting in Akure, Ondo State, Nigeria over eighteen months. Results :Twenty-one diagnoses of lymphocytic colitis were made from a pool of one hundred and twenty-two colonosco pies done between December 2021 and May 2023. There were slightly more females diagnosed with an M: F ratio of 3:4 with a mean (SD) age of 52.2 (± 14.3) years. All of the patients had a history of passage of watery diarrhoea while normal colonoscopy findings were present in 87.5%. The mean (SD) time to diagnosis in five of these study subjects was 18.4 ± 9.1 months.These patients had standard medical treatment with good outcomes. Conclusion : In sub-Saharan Africa, lymphocytic diarrhoea is a treatable cause of chronic diarrhoea. It is important to refer patients with chronic diarrhoea to facilities where they can benefit from the expertise of endoscopists and pathologists. an M: F ratio of 3:4 with a mean (SD) age of 52.2 (± 14.3) years. All of the patients had a history of passage of watery diarrhoea while normal colonoscopy findings were present in 87.5%. The mean (SD) time to diagnosis in five of these study subjects was 18.4 ± 9.1 months.These patients had standard medical treatment with good outcomes. Conclusion :In sub-Saharan Africa, lymphocytic diarrhoea is a treatable cause of chronic diarrhoea. It is important to refer patients with chronic diarrhoea to facilities where they can benefit from the expertise of endoscopists and pathologists.en_US
dc.identifier.affiliationsKenechukwu Okonkwo, Lecturer, Department of Medicine, University of Medical Sciences, Ondo, Nigeriaen_US
dc.identifier.affiliationsOlusegun Ojo, Professor, Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University, Ileife, Nigeriaen_US
dc.identifier.affiliationsOmolade Betiku, Lecturer , Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University, Ileife, Nigeria.en_US
dc.identifier.citationOkonkwo K, Ojo O, Betiku O . Lymphocytic colitis: an Important but Underdiagnosed Cause of Chronic Diarrhoea in Adult Nigerians. International Journal of Medical Research & Review . 2024 May ; 12(3): 84-92en_US
dc.identifier.issn2320-8686
dc.identifier.issn2321-127X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231064
dc.languageenen_US
dc.publisherSiddharth Health Research and Social Welfare Societyen_US
dc.relation.issuenumber3en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.17511/ijmrr.2024.i03.03en_US
dc.subjectLymphocytic colitisen_US
dc.subjectchronic diarrhoeaen_US
dc.subjectNigeriaen_US
dc.titleLymphocytic colitis: an Important but Underdiagnosed Cause of Chronic Diarrhoea in Adult Nigeriansen_US
dc.typeJournal Articleen_US
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