Protective effect of alcoholic extract of Entada pursaetha DC. against CCl4-induced hepatotoxicity in rats.

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dc.contributor.authorGupta, Gaurav
dc.contributor.authorMore, Amar Sunil
dc.contributor.authorKumari, Rashmi Rekha
dc.contributor.authorLingaraju, Madhu Cholenahalli
dc.contributor.authorKumar, Dhirendra
dc.contributor.authorKumar, Dinesh
dc.contributor.authorMishra, Santosh Kumar
dc.contributor.authorTandan, Surender Kumar
dc.date.accessioned2014-04-29T12:36:48Z
dc.date.available2014-04-29T12:36:48Z
dc.date.issued2014-03
dc.description.abstractThe alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and total bilirubin, lactate dehydrogenase; by lowering hepatic levels of malonaldehyde, nitrate-nitrite, myeloperoxidase activity; enhancing activities of antioxidant enzymes, superoxide dismutase, catalase and increasing reduced glutathione levels in liver, which suggests the antioxidant property of PSE. Histopathological studies also supported the above biochemical parameters. The results suggested that alcoholic extract of E. pursaetha possesses significant hepatoprotective activity in CCl4-induced acute hepatotoxicity in rats and this is likely to be mediated through its antioxidant activities.en_US
dc.identifier.citationGupta Gaurav, More Amar Sunil, Kumari Rashmi Rekha, Lingaraju Madhu Cholenahalli, Kumar Dhirendra, Kumar Dinesh, Mishra Santosh Kumar, Tandan Surender Kumar. Protective effect of alcoholic extract of Entada pursaetha DC. against CCl4-induced hepatotoxicity in rats. Indian Journal of Experimental Biology. 2014 Mar; 52(3): 207-214.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150350
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/27344en_US
dc.subjectAntioxidanten_US
dc.subjectCCl4en_US
dc.subjectEntada pursaethaen_US
dc.subjectHepatoprotection Liver toxicityen_US
dc.subject.meshAnimals
dc.subject.meshAntioxidants --metabolism
dc.subject.meshCarbon Tetrachloride --toxicity
dc.subject.meshCatalase --metabolism
dc.subject.meshDrug-Induced Liver Injury --drug therapy
dc.subject.meshDrug-Induced Liver Injury --pathology
dc.subject.meshFabaceae --chemistry
dc.subject.meshGlutathione --metabolism
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshLiver --drug effects
dc.subject.meshLiver --pathology
dc.subject.meshPlant Extracts --administration & dosage
dc.subject.meshPlant Extracts --chemistry
dc.subject.meshRats
dc.subject.meshSuperoxide Dismutase --metabolism
dc.titleProtective effect of alcoholic extract of Entada pursaetha DC. against CCl4-induced hepatotoxicity in rats.en_US
dc.typeArticleen_US
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