The Effects of Cosmos caudatus (Ulam Raja) on Detoxifying Enzymes in Extrahepatic Organs in Mice.

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dc.contributor.authorAbdullah, Azman
dc.contributor.authorDhaliwal, Kezreen Kaur
dc.contributor.authorRoslan, Nur Nabillah Fahana
dc.contributor.authorLee, Chai Hui
dc.contributor.authorKalaiselvam, Murali
dc.contributor.authorMiszard, Harizz Radman
dc.contributor.authorSaad, Qodriyah Haji Mohd
dc.contributor.authorYusof, Kamisah
dc.contributor.authorJaarin, Kamsiah
dc.date.accessioned2015-07-06T04:21:11Z
dc.date.available2015-07-06T04:21:11Z
dc.date.issued2015-01
dc.description.abstract‘Ulam Raja’ or Cosmos caudatus is a common appetizer (ulam) consumed by the Malay community in Malaysia. However, in vivo studies pertaining to its antioxidant and chemoprotective properties are lacking. This study was done to determine the effects of Cosmos caudatus on detoxifying enzymes in extrahepatic organs (lungs, kidneys and stomach) in mice. Thirty adult male white mice were treated orally for 21 days with different doses of ‘Ulam Raja’ aqueous extract (UR) (100, 500, 1000mg/kg). The control group was given normal saline by oral gavage. Mice fed with diet containing 0.5% butylated hydroxyanisole (BHA) were used as positive control. After 21 days, the mice were sacrificed and extrahepatic organs were harvested. The activities of several detoxifying enzymes [catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), DT-diaphorase (DTD)] were measured. Lipid peroxidation level was determined by measuring malondialdehyde (MDA) concentration. In lungs, 100, 500 & 1000 mg/kg UR oral supplementation resulted in significant increases in CAT, SOD and GST activities. DTD activity in lungs was significantly increased in mice treated with 1000mg/kg UR. MDA levels in lungs were significantly decreased in mice treated with 100mg/kg & 500 mg/kg UR but was significantly increased in mice treated with 1000mg/kg UR. In kidneys, DTD activity was significantly increased in mice treated with 1000mg/kg UR. In stomach, CAT activity was significantly increased in mice treated with 1000mg/kg UR. The results showed that Cosmos caudatus supplementation in mice could protect extrahepatic organs from xenobiotic and oxidative injury. This indicates that consumption of ‘Ulam Raja’ might be a useful chemoprotective measure.en_US
dc.identifier.citationAbdullah Azman, Dhaliwal Kezreen Kaur, Roslan Nur Nabillah Fahana, Lee Chai Hui, Kalaiselvam Murali, Miszard Harizz Radman. Saad Qodriyah Haji Mohd, Yusof Kamisah, Jaarin Kamsiah. The Effects of Cosmos caudatus (Ulam Raja) on Detoxifying Enzymes in Extrahepatic Organs in Mice. Journal of Applied Pharmaceutical Science. 2015 Jan; 5(1): 82-88.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159076
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=1418en_US
dc.subjectCosmos caudatusen_US
dc.subjectmiceen_US
dc.subjectextrahepatic organsen_US
dc.subjectdetoxifying enzymesen_US
dc.subjectantioxidanten_US
dc.titleThe Effects of Cosmos caudatus (Ulam Raja) on Detoxifying Enzymes in Extrahepatic Organs in Mice.en_US
dc.typeArticleen_US
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