Topical 002% Mitomycin C for management of primary corneal-conjunctival intraepithelial neoplasia as primary therapy: A long term follow up

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dc.contributor.authorManoher, JMen_US
dc.contributor.authorPraveenaen_US
dc.contributor.authorKochar, Aen_US
dc.contributor.authorChauhan, Aen_US
dc.date.accessioned2019-12-02T09:51:02Z
dc.date.available2019-12-02T09:51:02Z
dc.date.issued2016
dc.description.abstractBackground: The corneal-conjunctival intraepithelial neoplasia (CCIN) is an ocular surface neoplasia commonly found among populations exposed to strong UV light. Although surgical excision is mainstay treatment, topical Mitomycin-C (MMC) 0.02% has been tried as a sole therapeutic treatment of non- invasive Ocular Surface Squamous Neoplasia (OSSN). Aim: The aim of this study was to report the long term outcome of treatment of non invasive ocular surface squamous neoplasia with topical Mitomycin C (0.02%) as primary therapy. Materials and methods: Total six eyes of six patients with CCIN were treated with topical mitomycin C (0.02%) alone as a sole therapy. All patients received topical MMC (0.02%) four times daily as a cycle therapy of two week ON and two week OFF for 12 weeks. The patients were followed up to two years. Results: All patients showed total cure with no recurrence during 2 years follow up period. Ocular irritation and mild conjunctival hyperemia were observed in 4 eyes during treatment with MMC. There were no serious complications noted at the end of the follow-up period. Conclusion: We concluded that Topical Mitomycin C (0.02%) may be used as a sole therapeutic treatment of non invasive Ocular surface squamous neoplasia with close on going follow-up.en_US
dc.identifier.affiliationsProfessor and Head, Department of Ophthalmology, Sardar Patel Medical College, Bikaner, Rajasthan, Indiaen_US
dc.identifier.affiliationsResident, Department of Ophthalmology, Sardar Patel Medical College, Bikaner, Rajasthan, India, praveenatandon1108@gmail.comen_US
dc.identifier.affiliationsProfessor, Department of Ophthalmology, Sardar Patel Medical College, Bikaner, Rajasthan, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Ophthalmology, Sardar Patel Medical College, Bikaner, Rajasthan, Indiaen_US
dc.identifier.citationManoher JM, Praveena, Kochar A, Chauhan A. Topical 002% Mitomycin C for management of primary corneal-conjunctival intraepithelial neoplasia as primary therapy: A long term follow up. International Archives of Integrated Medicine. 2016 Aug; 3(8): 16-22en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186202
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber8en_US
dc.relation.volume3en_US
dc.subjectOcular Surface Squamous Neoplasia (OSSN)en_US
dc.subjectMitomycin C (MMC)en_US
dc.subjectCorneal-Conjunctival Intraepithelial Neoplasia (CCIN)en_US
dc.titleTopical 002% Mitomycin C for management of primary corneal-conjunctival intraepithelial neoplasia as primary therapy: A long term follow upen_US
dc.typeJournal Articleen_US
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