A prospective study comparing the safety and efficacy of combination of aceclofenac and thiocolchicoside against aceclofenac alone in low back pain

Simple item page
dc.contributor.authorNellika, Aparna Mathummalen_US
dc.contributor.authorMothalampet, Anuradhaen_US
dc.contributor.authorRajagopal, Soorajen_US
dc.date.accessioned2020-04-23T07:48:20Z
dc.date.available2020-04-23T07:48:20Z
dc.date.issued2018-02
dc.description.abstractBackground: Aceclofenac is a non steroidal anti-inflammatory drug commonly prescribed in patients with acute low back pain. Thiocolchicoside is a skeletal muscle relaxant which is used in combination with NSAIDs. The efficacy of a combination of aceclofenac and thiocolchicoside has to be proved over aceclofenac alone in patients with acute low back pain. Objective of this study was to compare the safety and efficacy of a combination of aceclofenac and thiocolchicoside against aceclofenac alone in patients with acute low back pain.Methods: This study was undertaken as a prospective comparative study. Patients with acute low back pain receiving either aceclofenac 100 mg or a combination of aceclofenac 100 mg and thiocolchicoside 4 mg twice daily were enrolled in the study and were divided into two groups of 50 each. The primary efficacy parameter was pain intensity measured on a visual analogue scale. Adverse effects if any were monitored at the follow up visit.Results: At the start of the study, pain intensity, measured on visual analogue scale was comparable in both the groups. At the end point, there was a reduction in pain intensity in both the groups and the reduction was more significant in the combination group (p <0.001). Adverse effects reported in both the groups were found to be comparable.Conclusions: Combination of aceclofenac and thiocolchicoside is superior to aceclofenac alone in patients with acute low back pain.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Government Medical College, Kozhikode, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Physical Medicine and Rehabilitation, Government Medical College, Kozhikode, Kerala, Indiaen_US
dc.identifier.citationNellika Aparna Mathummal, Mothalampet Anuradha, Rajagopal Sooraj. A prospective study comparing the safety and efficacy of combination of aceclofenac and thiocolchicoside against aceclofenac alone in low back pain. International Journal of Basic & Clinical Pharmacology. 2018 Feb; 7(2): 333-336en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199572
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20180108en_US
dc.subjectAceclofenacen_US
dc.subjectLow back painen_US
dc.subjectThiocolchicosideen_US
dc.subjectVisual Analogue Scaleen_US
dc.titleA prospective study comparing the safety and efficacy of combination of aceclofenac and thiocolchicoside against aceclofenac alone in low back painen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijbcp2018v7n2p333.pdf
Size:
360.14 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Basic & Clinical Pharmacology