Evaluation of Random Urine Sample Protein-Cretinine Ratio as an Index of Quantitative Proteinuria
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Date
2004-07
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Abstract
The present study was conducted to find out a correlation between protein to creatinine (PC) ratio in
random sample and 24 hr. urinary protein (UP) in patients with proteinuria with normal renal functions
(serum cretinine<1.5 mg %) -group-I, with impaired renal functions, mild to moderate (s.cretinine
1.5-4.0mg%) group-II and advance renal failure (s.cretinine >4.0mg%) -group-III. 24 hr. and a
random urine sample was taken for each patient and was tested for protein and creatinine. PC ratio
was found in each random sample. The mean 24 hr.UP (g/24 hr.) estimated by 24 hr. urine collection
was 1.15± 0.97, 3.26 ±1.34 and 7.39±2.19 in group I, II and III respectively. However, the mean UP
estimated by random sample was 1.35±1.09, 3.94±1.93 and 10.38±3.70 in group-1, group-II and
group-III respectively. P value was statistically insignificant in group 1 & II. However, there was
significant difference in values in group-III (P=0.012). Coefficient of correlation on univariate analysis
was r=0.889 in group-I, 0.788 in group-II and 0.375 in group-III indicating a significant correlation in
results in groupI and II and not in group-III. The results in the study have shown that single voided
urine method of estimating quantitative proteinuria holds its value in patients with normal, as well as
in mild to moderately impaired renal functions. However, this method does not hold good for patients
with severely impaired renal functions.
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Keywords
Proteinuria, Protein to creatinine ratio
Citation
Garg Sandeep, Gupta Alok Kumar, Rohtgi Anurag, Sharma SK. Evaluation of Random Urine Sample Protein-Cretinine Ratio as an Index of Quantitative Proteinuria. JK Science Journal of Medical Education and Research. 2004 Jul-Sept;6(3): 134-137