Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.

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dc.contributor.authorKaur, Amandeep
dc.contributor.authorSingh, Ranvir
dc.contributor.authorDey, Chinmoy Sankar
dc.contributor.authorSharma, Shyam Sundar
dc.contributor.authorBhutani, Kamlesh K
dc.contributor.authorSingh, Inder Pal
dc.date.accessioned2013-02-07T04:34:41Z
dc.date.available2013-02-07T04:34:41Z
dc.date.issued2010-03
dc.description.abstractHexane, chloroform and ethyl acetate extracts (100 µg/ml) of Alpinia galanga rhizomes exhibited significant activity in vitro against promastigotes of L. donovani. Twelve compounds namely, methyleugenol (1), p-coumaryl diacetate (2), 1'-acetoxychavicol acetate (3), 1'-acetoxyeugenol acetate (4), trans-p-acetoxycinnamyl alcohol (5), trans-3,4-dimethoxycinnamyl alcohol (6), p-hydroxybenzaldehyde (7), p-hydroxycinnamaldehyde (8), trans-p-coumaryl alcohol (9), galangin (10), trans-p-coumaric acid (11) and galanganol B (12) were isolated from these extracts. Of these, compounds 2, 3, 4 and 5 were found most active in vitro against promastigotes of L. donovani with IC50 values of 39.3, 32.9, 18.9 and 79.9 µM respectively. This is the first report of antileishmanial activity of the extracts and isolated constituents of A. galanga.en_US
dc.identifier.citationKaur Amandeep, Singh Ranvir, Dey Chinmoy Sankar, Sharma Shyam Sundar, Bhutani Kamlesh K, Singh Inder Pal. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd. Indian Journal of Experimental Biology. 2010 Mar; 48(3): 314-317.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144974
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/7407en_US
dc.subjectAlpinia galangaen_US
dc.subjectLeishmania donovanien_US
dc.subjectLeishmaniasisen_US
dc.subjectPhenylpropanoidsen_US
dc.subjectPromastigotesen_US
dc.titleAntileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.en_US
dc.typeArticleen_US
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