Hepato and reno protective action of Calendula officinalis L. flower extract.

Simple item page
dc.contributor.authorPreethi, Korengath Chandranen_US
dc.contributor.authorKuttan, Ramadasanen_US
dc.date.accessioned2009-05-28T15:02:46Z
dc.date.available2009-05-28T15:02:46Z
dc.date.issued2009-03-02en_US
dc.description.abstractFlower extract of C. officinalis L. was evaluated for its protective effect against CCl4 induced acute hepatotoxicity and cisplatin induced nephrotoxicity. The activities of serum marker enzymes of liver injury like glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP) which were increased by CCl4 injection was found to be significantly reduced by the pretreatment of the flower extract at 100 and 250 mg/kg body weight. The lipid peroxidation in liver, the marker of membrane damage and the total bilirubin content in serum were also found to be at significantly low level in the extract pretreated group, indicating its protective role. The kidney function markers like urea and creatinine were significantly increased in cisplatin treated animals. However, their levels were found to be lowered in the extract pretreated groups (100 and 250 mg/kg body weight). Moreover, cisplatin induced myelosuppression was ameliorated by the extract pretreatment. Treatment with the extract produced enhancement of antioxidant enzymes--superoxide dismutase and catalase and glutathione. Results suggest a protective role of the flower extract of C. officinalis against CCl4 induced acute hepatotoxicity and cisplatin induced nephrotoxicity. Extract has been found to contain several carotenoids of which lutein, zeaxanthin and lycopene predominates. Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals.en_US
dc.description.affiliationDepartment of Biochemistry Amala Cancer Research Centre, Amala Nagar, Thrissur, India, 680 555.en_US
dc.identifier.citationPreethi KC, Kuttan R. Hepato and reno protective action of Calendula officinalis L. flower extract. Indian Journal of Experimental Biology. 2009 Mar; 47(3): 163-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61486
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/3293/1/IJEB%2047%283%29%20163-168.pdfen_US
dc.subject.meshAcute Disease
dc.subject.meshAnimals
dc.subject.meshAntioxidants --administration & dosage
dc.subject.meshAntioxidants --therapeutic use
dc.subject.meshCalendula --chemistry
dc.subject.meshCarbon Tetrachloride
dc.subject.meshCisplatin
dc.subject.meshDrug-Induced Liver Injury --blood
dc.subject.meshDrug-Induced Liver Injury --etiology
dc.subject.meshDrug-Induced Liver Injury --metabolism
dc.subject.meshDrug-Induced Liver Injury --prevention & control
dc.subject.meshFemale
dc.subject.meshFlowers --chemistry
dc.subject.meshKidney Diseases --blood
dc.subject.meshKidney Diseases --chemically induced
dc.subject.meshKidney Diseases --metabolism
dc.subject.meshKidney Diseases --prevention & control
dc.subject.meshKidney Function Tests
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshLiver Function Tests
dc.subject.meshMice
dc.subject.meshPlant Extracts --administration & dosage
dc.subject.meshPlant Extracts --therapeutic use
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshTreatment Outcome
dc.subject.meshAlcohol Drinking --metabolism
dc.subject.meshAmino Acids --analysis
dc.subject.meshAnimals
dc.subject.meshAtherosclerosis --blood
dc.subject.meshAtherosclerosis --prevention & control
dc.subject.meshGarlic --chemistry
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshLipids --blood
dc.subject.meshLiver --drug effects
dc.subject.meshLiver --enzymology
dc.subject.meshLiver --metabolism
dc.subject.meshLiver Function Tests
dc.subject.meshMale
dc.subject.meshRats
dc.subject.meshSoybean Proteins --administration & dosage
dc.subject.meshSoybean Proteins --chemistry
dc.subject.meshSoybean Proteins --pharmacology
dc.subject.meshVegetable Proteins --administration & dosage
dc.subject.meshVegetable Proteins --chemistry
dc.subject.meshVegetable Proteins --pharmacology
dc.titleHepato and reno protective action of Calendula officinalis L. flower extract.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology