A PROSPECTIVE OBSERVATIONAL STUDY ON ANTIBIOTIC USAGE TRENDS, RISK FACTORS AND 28 DAYS MORTALITY RATE ASSOCIATED WITH VENTILATOR-ASSOCIATED PNEUMONIA AMONG MEDICAL ICU PATIENTS: INSIGHTS FROM A TERTIARY CARE HOSPITAL

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dc.contributor.authorPARTHASARATHY, Ren_US
dc.contributor.authorSUNNY, AA.en_US
dc.date.accessioned2025-05-12T07:20:51Z
dc.date.available2025-05-12T07:20:51Z
dc.date.issued2024-08
dc.description.abstractObjective: This study was conducted to investigate the antibiotic usage, risk factors and mortality associated with the development of VAP (Ventilator Associated Pneumonia). Methods: An open–labelled, prospective, observational (case-control) study was carried out for 6 mo in the Department of Critical Care Medicine. Initial screening was done based on inclusion and exclusion criteria and 58 patients were found eligible. The statistical analysis was done using the Chi-Square test and t-test. Results: The incidence of VAP in our study was 6.07%. Prolonged hospitalisation (p=0.00) and ICU stay (p=0.00) showed a statistically significant association with the development of VAP and they possessed a high risk of carbapenem-resistant organisms in the age group more than 60 years. Colistin therapy alone and/or combined with tigecycline therapy showed 100% survival. SOFA (Sequential Organ Failure Assessment) scoring done before and after VAP diagnosis showed a significant difference (p<0.005). Our study revealed that mortality was high in patients with SOFA score range of 7-9. Conclusion: The lower incidence of VAP points out the good infection control practices in the ICU (Intensive Care Unit). Late-onset VAP was more prevalent with Acinetobacter baumannii. Prolonged hospitalization and ICU stay were the significant risk factors. Colistin therapy alone and/or in combination with tigecycline was the most effective treatment.en_US
dc.identifier.affiliationsDepartment of Pharmacy Practice, PSG College of Pharmacy, Coimbatore-641004, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Neurology, KMCH Hospitals, Coimbatore-641004, Tamil Nadu, Indiaen_US
dc.identifier.citationPARTHASARATHY R, SUNNY AA.. A PROSPECTIVE OBSERVATIONAL STUDY ON ANTIBIOTIC USAGE TRENDS, RISK FACTORS AND 28 DAYS MORTALITY RATE ASSOCIATED WITH VENTILATOR-ASSOCIATED PNEUMONIA AMONG MEDICAL ICU PATIENTS: INSIGHTS FROM A TERTIARY CARE HOSPITAL . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Aug; 16(8): 21-26en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246460
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber8en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2024v16i8.51599en_US
dc.subjectVentilator-associated Pneumoniaen_US
dc.subjectMortality rateen_US
dc.subjectAntibioticsen_US
dc.subjectPrescribing patternen_US
dc.titleA PROSPECTIVE OBSERVATIONAL STUDY ON ANTIBIOTIC USAGE TRENDS, RISK FACTORS AND 28 DAYS MORTALITY RATE ASSOCIATED WITH VENTILATOR-ASSOCIATED PNEUMONIA AMONG MEDICAL ICU PATIENTS: INSIGHTS FROM A TERTIARY CARE HOSPITALen_US
dc.typeJournal Articleen_US
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