A prospective study to compare the efficacy of tacrolimus vs cyclosporine in vernal keratoconjunctivitis in children in India

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dc.contributor.authorChoudhary, Priyaen_US
dc.contributor.authorSingh, Satya Prakashen_US
dc.contributor.authorChaurasia, Rakesh Chandraen_US
dc.contributor.authorJindal, Meenakshien_US
dc.date.accessioned2020-04-23T07:56:23Z
dc.date.available2020-04-23T07:56:23Z
dc.date.issued2019-06
dc.description.abstractBackground: Vernal keratoconjunctivitis (VKC) is a chronic allergic conjunctival disease. Immunomodulatory drugs like cyclosporine is being used for its treatment. Tacrolimus is another immunomodulator drug that can be used in VKC. This study was done to compare the efficacy of tacrolimus and cyclosporine in VKC.Methods: This prospective study was conducted on 60 patients of either sex by dividing them into two groups. The first group was treated with cyclosporine (0.05%) ophthalmic eye drop and second group with tacrolimus (0.03%) ophthalmic ointment. Total five objective signs (hyperaemia, oedema, papillae, corneal involvement and tantra’s dot) and five subjective symptoms (itching, tearing, foreign body sensation, discharge and photophobia) data was collected and tabulated for statistical analysis.Results: Authors found TSSS in both groups decrease significantly (p <0.05 or p <0.01 or p <0.001) at all post periods as compared to respective predecessor periods except 4 weeks to 6 weeks in cyclosporine group and 6 weeks to 8 weeks in tacrolimus group. Similarly, for each period, on comparing the mean TSSS between the groups TSSS between the groups at all periods does not differed statistically though at final evaluation (mean change from baseline to 8 weeks), it improved 5.2% more in tacrolimus group (83.7%) than cyclosporine group (78.5%). Similarly, TOSS also decreased at all post periods except 4 weeks to 6 weeks, and 6 weeks to 8 weeks in cyclosporine group and 6 weeks to 8 weeks in tacrolimus group. Improvement in scores was 11.6% more in tacrolimus (81.6%) than cyclosporine (70.0%). Cyclosporine eye drops are associated with burning sensation and redness of eyes while transient ocular irritation was only observed side effect with tacrolimus.Conclusions: The study found tacrolimus is clinically better drug for treatment of vernal keratoconjunctivitis than cyclosporine and is also cost effective.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Muzaffarnagar Medical College Muzaffarnagar, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Muzaffarnagar Medical College Muzaffarnagar, Uttar Pradesh, Indiaen_US
dc.identifier.citationChoudhary Priya, Singh Satya Prakash, Chaurasia Rakesh Chandra, Jindal Meenakshi. A prospective study to compare the efficacy of tacrolimus vs cyclosporine in vernal keratoconjunctivitis in children in India. International Journal of Basic & Clinical Pharmacology. 2019 Jun; 8(6): 1297-1302en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200196
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20192193en_US
dc.subjectTacrolimusen_US
dc.subjectCyclosporineen_US
dc.subjectVernal keratoconjunctivitisen_US
dc.subjectImmunomodulatoryen_US
dc.titleA prospective study to compare the efficacy of tacrolimus vs cyclosporine in vernal keratoconjunctivitis in children in Indiaen_US
dc.typeJournal Articleen_US
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