Evaluation of glutathione and ascorbic acid as suppressors of drug-induced lipid peroxidation.

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dc.contributor.authorRoy, Ken_US
dc.contributor.authorDe, A Uen_US
dc.contributor.authorSengupta, Cen_US
dc.date.accessioned2009-05-28T13:09:09Z
dc.date.available2009-05-28T13:09:09Z
dc.date.issued2000-06-16en_US
dc.description.abstractIn different sets of experiment lipid peroxidation induction capacity of two drugs, viz., ceftizoxime sodium, a third generation cephalosporin antibiotic, and acyclovir, an antiviral agent, was studied using goat whole blood as the lipid source. Ceftizoxime sodium caused significant extent of lipid peroxidation. Lipid peroxidation being a toxicity mediating process, such observation may be related to the toxic potential of the drug. Insignificant induction of lipid peroxidation was found in case of acyclovir and this is in good agreement with the safety record of the drug. Glutathione and ascorbic acid could significantly reduce ceftizoxime sodium induced lipid peroxidation, suggesting that free radical scavenging action of antioxidants may be exploited by possible antioxidant co-therapy to reduce iatrogenicity of the drug in persons with impaired endogenous antioxidant defence. Glutathione and ascorbic acid appear to be promising candidates for further investigation in this regard.en_US
dc.description.affiliationDivision of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700032.en_US
dc.identifier.citationRoy K, De AU, Sengupta C. Evaluation of glutathione and ascorbic acid as suppressors of drug-induced lipid peroxidation. Indian Journal of Experimental Biology. 2000 Jun; 38(6): 580-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59030
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcyclovir --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --pharmacologyen_US
dc.subject.meshAscorbic Acid --pharmacologyen_US
dc.subject.meshCeftizoxime --pharmacologyen_US
dc.subject.meshDepression, Chemicalen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshFree Radical Scavengers --pharmacologyen_US
dc.subject.meshGlutathione --pharmacologyen_US
dc.subject.meshGoats --blooden_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshMalondialdehyde --analysisen_US
dc.subject.meshOxidation-Reductionen_US
dc.subject.meshOxidative Stress --drug effectsen_US
dc.subject.meshSafetyen_US
dc.titleEvaluation of glutathione and ascorbic acid as suppressors of drug-induced lipid peroxidation.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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