Anticonvulsant effect of cytoskeletal depolymerizers in combination with potassium channel opener and adenylate cyclase activator; a causative link with nerve growth factor?

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dc.contributor.authorTyagi, M Gen_US
dc.contributor.authorJose, V Men_US
dc.date.accessioned2009-05-28T15:55:42Z
dc.date.available2009-05-28T15:55:42Z
dc.date.issued2001-05-21en_US
dc.description.abstractAnticonvulsant effect of cytoskeletal depolymerizing drugs in combination with potassium channel (KATP) opener and adenylate cyclase activator was evaluated in animal models of epilepsy. Seizures were induced in the animals by subjecting them to maximal electroshock (MES) or by injecting a chemical convulsant, pentylenetetrazole (PTZ). Moreover a correlation with the nerve growth factor (NGF) was also investigated. The anticonvulsant effect of minoxidil (1200 micrograms/kg i.p.) and Deacetylforskolin (600 micrograms/kg i.p.) was significantly enhanced in the mice pre-treated with cytoskeletal depolymerizing drugs. On the other hand nerve growth factor potentiated the convulsive phenomenon and decreased the seizure threshold in both the electroshock and chemically induced convulsions. Another interesting feature was the interaction of cytochalasin B, a microfilament disrupter in preventing the action of mNGF and PTZ. This study demonstrates the importance of interaction between cytoskeletal structures and signalling molecules in determining the convulsive threshold. This study clearly points to the importance of the nerve growth factor in convulsive phenomenon.en_US
dc.description.affiliationDepartment of Pharmacology, Christian Medical College, Bagayam, Vellore 632 002.en_US
dc.identifier.citationTyagi MG, Jose VM. Anticonvulsant effect of cytoskeletal depolymerizers in combination with potassium channel opener and adenylate cyclase activator; a causative link with nerve growth factor? Indian Journal of Experimental Biology. 2001 May; 39(5): 425-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62592
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdenylate Cyclase --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticonvulsants --administration & dosageen_US
dc.subject.meshCytochalasin B --administration & dosageen_US
dc.subject.meshCytoskeleton --drug effectsen_US
dc.subject.meshEnzyme Activation --drug effectsen_US
dc.subject.meshEpilepsy --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshForskolin --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMinoxidil --administration & dosageen_US
dc.subject.meshNerve Growth Factor --administration & dosageen_US
dc.subject.meshPotassium Channels --drug effectsen_US
dc.subject.meshSignal Transductionen_US
dc.titleAnticonvulsant effect of cytoskeletal depolymerizers in combination with potassium channel opener and adenylate cyclase activator; a causative link with nerve growth factor?en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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