Zona pellucida glycoproteins based immunocontraceptive vaccines: strategies for development and their applications.

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dc.contributor.authorGupta, Satish Ken_US
dc.contributor.authorChoudhury, Sangeetaen_US
dc.contributor.authorSrivastava, Neeluen_US
dc.contributor.authorRavi, Chitraen_US
dc.date.accessioned2009-05-28T14:23:14Z
dc.date.available2009-05-28T14:23:14Z
dc.date.issued2003-07-17en_US
dc.description66 references.en_US
dc.description.abstractThe mammalian oocyte is surrounded by an extra-cellular matrix, the zona pellucida (ZP), composed of three major glycoproteins (ZP1, ZP2 and ZP3). The ZP glycoproteins, by virtue of their tissue specificity and critical role during mammalian fertilization, have emerged as potential candidate antigens for the development of an immunocontraceptive vaccine. Molecular characterization of ZP glycoproteins from several species, reveals a variable degree of homology among the deduced primary amino acid sequences, which provided an opportunity to undertake active immunization studies in heterologous animal models. Active immunization of various animal species with either native ZP glycoproteins or those obtained by recombinant DNA technology led to the inhibition of fertility. Thus ZP glycoproteins based immunocontraceptive vaccines offer an attractive proposition for controlling wild life population. To make it a practical proposition, additional research inputs are required to optimize and devise novel strategies for vaccine delivery. Observed ovarian dysfunction, often associated with immunization by ZP glycoproteins is one of the major stumbling blocks for their use in humans. Ongoing studies to delineate appropriate B cell epitopes of ZP glycoproteins that are devoid of oophoritogenic T-cell epitopes, which will inhibit fertility without concomitant oophoritis, will be critical to determine their feasibility for human use.en_US
dc.description.affiliationGamete Antigen Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India. skgupta@nii.res.inen_US
dc.identifier.citationGupta SK, Choudhury S, Srivastava N, Ravi C. Zona pellucida glycoproteins based immunocontraceptive vaccines: strategies for development and their applications. Indian Journal of Experimental Biology. 2003 Jul; 41(7): 682-93en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60642
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshContraception, Immunologic --methodsen_US
dc.subject.meshEgg Proteins --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Glycoproteins --immunologyen_US
dc.subject.meshReceptors, Cell Surface --immunologyen_US
dc.subject.meshVaccines, Contraceptiveen_US
dc.subject.meshZona Pellucida --chemistryen_US
dc.titleZona pellucida glycoproteins based immunocontraceptive vaccines: strategies for development and their applications.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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