Nuclear morphometric study of Non-Hodgkin’s Lymphoma (NHL)

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dc.contributor.authorErugula, SRen_US
dc.contributor.authorSujatha, Pen_US
dc.contributor.authorSameera, Aen_US
dc.contributor.authorReddy, BSen_US
dc.contributor.authorGovada, Sen_US
dc.contributor.authorSudhakar, G|en_US
dc.date.accessioned2019-12-02T09:52:22Z
dc.date.available2019-12-02T09:52:22Z
dc.date.issued2016
dc.description.abstractBackground: Assessment of nuclear morphology is crucial for the diagnosis of non-Hodgkin's lymphoma. The non-Hodgkin’s lymphomas (NHL) constitute a heterogenous group of lymphoid neoplasms that vary in clinical behavior, histology, immunology and genetic profile. The diversity makes it difficult to diagnose accurately and reproducibly under light microscopy. The nuclear features play a major role in categorizing non-Hodgkin's lymphomas. Materials and methods: The present study was conducted for a period of two years in the Department of Oral Pathology, MNR dental College and Hospital, Sangareddy, Telangana, India. We encountered only three cases of Non-Hodgkin Lymphomas and so we have borrowed the some Sridhar Reddy Erugula, P. Sujatha, Ayesha Sameera, B. Suresh Reddy, Jesudass Govada, G. Sudhakar, Kandukuri Mahesh Kumar. Nuclear morphometric study of Non-Hodgkin's Lymphoma (NHL). IAIM, 2016; 3(5): 58-63. Page 59 specimens of NHL from other hospitals in Hyderabad, India. Hematoxylin and Eosin (H and E) stained histological sections were selected and assessed for nuclear area, perimeter and nuclear size of 40 nuclei of tumour cells were measured using the Windows® based image analysis software Results: Total number of cases in our study was 15. The mean nuclear area, perimeter and nuclear size of neoplastic cells were studied. In our study, the mean nuclear area, perimeter and nuclear size of neoplastic cells were significantly high in large cell lymphomas as compared to intermediate cells and small cell lymphoma. P value was significant. Conclusion: Our study supports the assumption that nuclear morphometry offers a more objective and reproducible diagnostic method for subcategorizing lymphoid tumors than is currently possible by conventional histopathological techniques.en_US
dc.identifier.affiliationsSenior Lecturer, Department of Oral Pathology, MNR Dental College and Hospital, Sanga Reddy, Telangana State, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Pathology, Malla Reddy Institute of Medical Sciences, Hyderabad, Telangana State, Indiaen_US
dc.identifier.affiliationsConsultant, Oral Pathologist, Hyderabad, Telangana State, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of General Medicine, Maheswara Medical College, Telangana State, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Pedodontics and Preventive Dentistry, Government Dental College and Hospital, RIMS, Kadapa, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, RIMS, Kadapa, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Pathology, Malla Reddy Institute of Medical Sciences, Hyderabad, Telangana State, India, *Corresponding doctormaheshgoud@gmail.comen_US
dc.identifier.citationErugula SR, Sujatha P, Sameera A, Reddy BS, Govada S, Sudhakar G, Kumar KMK. Nuclear morphometric study of Non-Hodgkin’s Lymphoma (NHL). International Archives of Integrated Medicine. 2016 May; 3(5): 68-63en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186376
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber5en_US
dc.relation.volume3en_US
dc.subjectNon Hodgkin Lymphomasen_US
dc.subjectMorphometryen_US
dc.subjectImage analysisen_US
dc.subjectLarge Cell Lymphomaen_US
dc.subjectSmall Cellen_US
dc.titleNuclear morphometric study of Non-Hodgkin’s Lymphoma (NHL)en_US
dc.typeJournal Articleen_US
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