The Relationship Between eNOS & CCR2 Gene Polymorphism in Chronic Kidney Disease Patients
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Date
2024-01
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FORUM: Fraternity of national Research & pUblication Society of Medical sciences
Abstract
Background/Aims: A significant public health concern, chronic kidney disease is frequently brought on by hypertension, diabetes, nephrotoxic drugs and glomerulonephritis. It is possible that some patients' CKD develops earlier than expected even with appropriate treatment, suggesting the possibility of genetic factors contributing to the disease's development. Materials and Methods: The present study was conducted in the OPD and male and female medicine wards of Dhiraj Hospital, Pipariya, Vadodara, India. The Study duration was 6 months. Based on careful clinical assessment and judgement of treating physician patients having chronic kidney disease with age >18years were selected on the basis of KDIGO Classification of CKD. Results: During the study period, out of 146 patients selected, 62 met the criteria for the CKD in which CCR-2 and eNOS gene polymorphism were tested and compared. Conclusions: The investigation of the relationship between CCR-2 and eNOS and the aetiology of chronic kidney disease (CKD), as well as the age at which CKD onset and duration were compared, is a novel discovery in this study. The results of this study show a substantial relationship between the eNOS TT genotype and the CCR-2 GA genotype and stages of renal disease, as well as CKD and declining renal function. However, in the Indian population, CCR-2 and eNOS expression are unaffected by the age at which a disease first manifests, the length of the illness, or the etiology of CKD.
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Keywords
CKD, CCR-2, eNOS
Citation
Shah Prasen, Upadhyay Puneet, Darda Shubham, Vatsraj Dharmendra J., Trivedi Shaival. The Relationship Between eNOS & CCR2 Gene Polymorphism in Chronic Kidney Disease Patients. Indian Journal of Applied Basic Medical Sciences. 2024 Jan; 26A(1): 1-11