Aframomum subsericeum and Aframomum alboviolaceum leaf essential oils exhibit testosterone antagonistic and oestrogen synergic effects in male Wistar rats: potential candidates for prostate cancer treatment

Simple item page
dc.contributor.authorChiara Nange, A.en_US
dc.contributor.authorDjiogue, S.en_US
dc.contributor.authorBruno, Dupon, A. A.en_US
dc.contributor.authorBerlise, B. Y.en_US
dc.contributor.authorKamga, K. S.en_US
dc.contributor.authorDieudonné, N.en_US
dc.date.accessioned2024-09-24T06:13:57Z
dc.date.available2024-09-24T06:13:57Z
dc.date.issued2024-08
dc.description.abstractBackground: Aframomum species are routinely used as spices in many traditional Cameroonian meals due to their sweet fragrance. Many species of the Aframomum species are also used to treat cancer, pain, arthritis, and stomach disorders. This work was performed to determine the chemical composition, antiandrogenic, and estrogenic properties of Aframomum subsericeum and Aframomum alboviolaceum leaf essential oils. Methods: The chemical components of A. subsericeum and A. alboviolaceum essential oils were identified by gas chromatography-mass spectroscopy. The anti-androgenic and estrogenic properties were investigated in vivo in physically and chemically castrated Wistar rats, respectively. Results: Fifteen compounds versus nine compounds were identified in A. subsericeum and A. alboviolaceum essential oils, respectively. The main compounds of Aframomum subsericeum were cyclohexene, 1-methyl-4-(1-methylethylidene) (10.03%), ?-terpine (12.22%), and myrtenyl acetate (8.52%), while those of Aframomum alboviolaceum were ?-terpinene (20.07%), caryophyllene (11.58%), myrtenyl acetate (7.22%), and (1R)2, 6, 6 trimethylbicyclo [3.1.1] hept-2-ene (6.97%). The results of the anti-androgenic test reveal that both A. subsericeum and A. alboviolaceum induced a significant decrease in androgen-dependent organs, especially the prostate and seminal vesicle, at doses of 200 mg/kg and 100 mg/kg. Interestingly, A. alboviolaceum showed oestrogen synergic effects on the above organs. Conclusions: So, this study reveals mainly the presence of diterpenoids in both A. subsericeum and A. alboviolaceum, which are potential candidates for prostate cancer treatment. The in vivo results show that Aframomum leaf essential has antiandrogenic and oestrogen synergic properties, suggesting that the oils could provide a safe natural drug for prostate cancer treatment.en_US
dc.identifier.affiliationsDepartment of Animal Biology and Physiology, University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Animal Biology and Physiology, University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Animal Biology and Physiology, University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Pharmacotoxicology, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, P.O. Box 1364 Yaounde, Cameroonen_US
dc.identifier.affiliationsDepartment of Animal Biology and Physiology, University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroonen_US
dc.identifier.citationChiara Nange A., Djiogue S., Bruno Dupon A. A., Berlise B. Y., Kamga K. S., Dieudonné N.. Aframomum subsericeum and Aframomum alboviolaceum leaf essential oils exhibit testosterone antagonistic and oestrogen synergic effects in male Wistar rats: potential candidates for prostate cancer treatment. International Journal of Basic & Clinical Pharmacology. 2024 Jul; 13(4): 456-463en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226759
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20241644en_US
dc.subjectAframomum speciesen_US
dc.subjectAntiandrogenicity and oestrogenicityen_US
dc.subjectChemical compositionen_US
dc.subjectEssential oilsen_US
dc.titleAframomum subsericeum and Aframomum alboviolaceum leaf essential oils exhibit testosterone antagonistic and oestrogen synergic effects in male Wistar rats: potential candidates for prostate cancer treatmenten_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijbcp2024v13n4p456.pdf
Size:
495.53 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Basic & Clinical Pharmacology