Antioxidant and hepatoprotective activity of Flemingia tuberosa Dalzell in CCl4-induced hepatotoxicity in rats

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dc.contributor.authorMascarenhas, Reena Williamen_US
dc.contributor.authorShailajan, Sunitaen_US
dc.contributor.authorMenon, Sasikumaren_US
dc.date.accessioned2020-10-16T08:56:58Z
dc.date.available2020-10-16T08:56:58Z
dc.date.issued2020-06
dc.description.abstractFlemingia tuberosa Dalzell is an endemic species of the Western Ghats. It is an ethnomedicinal plant used to curedysentery and vaginal discharge. However, in this study, the hepatoprotective potency of the plant has been evaluatedas it contains flavonoids like kaempferol. The present study was conducted to investigate the hepatoprotective activityof the ethanolic extract of aerial parts of F. tuberosa against Carbon tetrachloride (CCl4)-induced toxicity in rats.The extract was standardized using a validated HPTLC method for kaempferol content. The antioxidant activityof the ethanolic extract of aerial parts of F. tuberosa was assessed by 1,1-diphenyl-2-picrylhydrazyl method. Thehepatoprotective activity was assessed against CCl4-induced liver intoxication, wherein the CCl4-induced albino Wistarrats were treated with three different doses of the standardized extract for 3 days. The results were compared with theestablished positive control, Silymarin. The protective effect on the liver was also monitored histopathologically usinglight and electron microscope and biochemically through observing the levels of biochemical enzymes. The extractshowed potent hepatoprotective activity. This study confirms the protective effect of the ethanolic extract of aerialparts of F. tuberosa against CCl4-induced hepatotoxicityen_US
dc.identifier.affiliationsHerbal Research Lab, Ramnarain Ruia Autonomous College, Mumbai 400 019, India.en_US
dc.identifier.affiliationsHerbal Research Lab, Ramnarain Ruia Autonomous College, Mumbai 400 019, India.en_US
dc.identifier.affiliationsTherapeutic Drug Monitoring Laboratory, Mumbai 400 022, India.en_US
dc.identifier.citationMascarenhas Reena William, Shailajan Sunita, Menon Sasikumar. Antioxidant and hepatoprotective activity of Flemingia tuberosa Dalzell in CCl4-induced hepatotoxicity in rats. Journal of Applied Pharmaceutical Science. 2020 Jun; 2020 Jun: 032-038en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210766
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10605en_US
dc.subjectFlemingiaen_US
dc.subjectendemicen_US
dc.subjectchromatographyen_US
dc.subjectantioxidanten_US
dc.subjecthepatoprotectiveen_US
dc.subjecthistopathologyen_US
dc.titleAntioxidant and hepatoprotective activity of Flemingia tuberosa Dalzell in CCl4-induced hepatotoxicity in ratsen_US
dc.typeJournal Articleen_US
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