Effect of Aerva lanata on calcium oxalate urolithiasis in rats.

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dc.contributor.authorSoundararajan, Pen_US
dc.contributor.authorMahesh, Ren_US
dc.contributor.authorRamesh, Ten_US
dc.contributor.authorBegum, V Hazeenaen_US
dc.date.accessioned2009-05-28T14:12:44Z
dc.date.available2009-05-28T14:12:44Z
dc.date.issued2006-12-21en_US
dc.description.abstractCalcium oxalate (CaOx) stone was induced in rats using 0.75% of ethylene glycol in drinking water for 28 days. Ethylene glycol treated rats showed significant increase in the activities of oxalate synthesizing enzymes such as glycolic acid oxidase (GAO) in liver and lactate dehydrogenase (LDH) in liver and kidney. CaOx crystal deposition, as indicated by increased excretion of stone-forming constituents in urine, such as calcium, oxalate, uric acid, phosphorus and protein and decreased concentration of inhibitors, such as citrate and magnesium was observed in ethylene glycol induced urolithic rats. Histopathological studies also confirmed the deposition of CaOx crystals. Administration of Aerva lanata aqueous suspension (2g/kg body wt/dose/day for 28 days) to CaOx urolithic rats had reduced the oxalate synthesizing enzymes, diminished the markers of crystal deposition in the kidney. The results of the present study confirmed that A. lanata can be used as an curative agent for urolithiasis.en_US
dc.description.affiliationDepartment of Siddha Medicine, Faculty of Science, Tamil University, Thanjavur 613 005, India.en_US
dc.identifier.citationSoundararajan P, Mahesh R, Ramesh T, Begum VH. Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian Journal of Experimental Biology. 2006 Dec; 44(12): 981-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60415
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6670/1/IJEB%2044%2812%29%20981-986.pdfen_US
dc.subject.meshAlcohol Oxidoreductases --metabolismen_US
dc.subject.meshAmaranthaceae --chemistryen_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Oxalate --metabolismen_US
dc.subject.meshL-Lactate Dehydrogenase --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshUrolithiasis --drug therapyen_US
dc.titleEffect of Aerva lanata on calcium oxalate urolithiasis in rats.en_US
dc.typeJournal Articleen_US
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