Doxycycline induced fixed drug eruption: a case report

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dc.contributor.authorAnandan, Isswariyaen_US
dc.contributor.authorSelvaraj, Nityaen_US
dc.contributor.authorGanesan, Suganyaen_US
dc.contributor.authorRajamohammad, Meher Alien_US
dc.contributor.authorJayabalan, Nalinidevien_US
dc.date.accessioned2020-04-23T07:52:34Z
dc.date.available2020-04-23T07:52:34Z
dc.date.issued2018-11
dc.description.abstractFixed drug eruption (FDE) is an adverse drug reaction seen with various groups of drugs are antibiotics such as trimethoprim -sulphamethoxazle, pencillin, tetracyclines, non steroidal anti- inflammatory drugs like ibuprofen, aspirin etc. Doxycycline belongs to tetracycline groups of antibiotics. We herein present the case of Doxycycline induced fixed drug eruption. A 35-year - old man presented to our hospital, with a 2-day history of itching and hyperpigmentation over the chest. Patient developed skin lesion 2 days after and he started taking Doxycycline 100 mg twice a day for skin infections. Dermatological examination revealed multiple well defined hyperpigmented patches seen over the anterior aspect of the chest. Doxycycline was discontinued immediately, and the skin lesions resolved spontaneously within 2 weeks. Causality assessment by using Naranjo adverse drug reaction probability scale and WHO Uppsala monitoring scale categorize the reaction as Doxycycline was the probable cause for the adverse drug reaction. Severity assessment by using modified Hartwig and Siegel ADR severity assessment scale labelled the reaction as mild-level 2. The causative drug or drugs and cross reactants should be avoided in future to prevent recurrence of similar skin reactions.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, Indiaen_US
dc.identifier.citationAnandan Isswariya, Selvaraj Nitya, Ganesan Suganya, Rajamohammad Meher Ali, Jayabalan Nalinidevi. Doxycycline induced fixed drug eruption: a case report. International Journal of Basic & Clinical Pharmacology. 2018 Nov; 7(11): 2264-2267en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199919
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20184337en_US
dc.subjectAntibioticen_US
dc.subjectDoxycyclineen_US
dc.subjectFixed drug eruptionen_US
dc.subjectTetracyclineen_US
dc.titleDoxycycline induced fixed drug eruption: a case reporten_US
dc.typeJournal Articleen_US
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