Vitamin B12 Deficiency and Hyperhomocysteinemia in Pre-Eclampsia: Assessing Biochemical Markers for Disease Prediction and Therapeutic Potential

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dc.contributor.authorKumar, Aen_US
dc.contributor.authorJain, J.en_US
dc.date.accessioned2025-05-14T09:45:20Z
dc.date.available2025-05-14T09:45:20Z
dc.date.issued2024-12
dc.description.abstractBackground: PE is a pregnancy-specific disorder with the onset of hypertension and proteinuria beyond 20 weeks of gestation. Several lines of evidence indicate that vitamin B12 deficiency and hyperhomocysteinemia (Hcy) may play a role in endothelial dysfunction in PE. Finding these markers could lead to earlier diagnoses and prevention in high-risk populations. Methods: We carried out a cross-sectional study of 120 pregnant women (60 with PE and 60 with normotensive controls). Vitamin B12 levels in serum and plasma homocysteine levels were measured. Independent t-tests were made to compare these markers, and correlations between these markers and PE severity were analyzed. Results: The PE group had significantly lower (p<0.01) Vitamin B12 and significantly higher (p<0.01) homocysteine. The existence of positive correlations between homocysteine and blood pressure supports a possible role of Hcy in endothelial dysfunction. Conclusion: PE risks rise in conjunction with Vitamin B12 deficiency and elevated homocysteine, and therefore these biomarkers could prove helpful in predicting PE early. The purpose of these assessments may be to improve outcomes by integrating them into prenatal care.en_US
dc.identifier.affiliationsPh.D. Scholar, Department of Biochemistry, Index Medical College, Indore – (M.P.) 452016, Indiaen_US
dc.identifier.affiliationsResearch Supervisor, Department of Biochemistry, Index Medical College, Indore – (M.P.), India452016, Indiaen_US
dc.identifier.citationKumar A, Jain J.. Vitamin B12 Deficiency and Hyperhomocysteinemia in Pre-Eclampsia: Assessing Biochemical Markers for Disease Prediction and Therapeutic Potential . SSR Institute of International Journal of Life Sciences. 2024 Dec; 10(6): 6406-6409en_US
dc.identifier.issn2581-8740
dc.identifier.issn2581-8732
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247956
dc.languageenen_US
dc.publisherSociety for Scientific Researchen_US
dc.relation.issuenumber6en_US
dc.relation.volume10en_US
dc.source.urihttps://iijls.com/currentissue/Vitamin_B12_Deficiency_Hyperhomocysteinemia_Biochemical_Markers_Disease_Prediction_Therapeutic_Potential.pdfen_US
dc.subjectPre-eclampsiaen_US
dc.subjectVitamin B12en_US
dc.subjectHomocysteineen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectBiomarkersen_US
dc.titleVitamin B12 Deficiency and Hyperhomocysteinemia in Pre-Eclampsia: Assessing Biochemical Markers for Disease Prediction and Therapeutic Potentialen_US
dc.typeJournal Articleen_US
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