Vitamin B12 Deficiency and Hyperhomocysteinemia in Pre-Eclampsia: Assessing Biochemical Markers for Disease Prediction and Therapeutic Potential
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Date
2024-12
Journal Title
Journal ISSN
Volume Title
Publisher
Society for Scientific Research
Abstract
Background: PE is a pregnancy-specific disorder with the onset of hypertension and proteinuria beyond 20 weeks of gestation. Several lines of evidence indicate that vitamin B12 deficiency and hyperhomocysteinemia (Hcy) may play a role in endothelial dysfunction in PE. Finding these markers could lead to earlier diagnoses and prevention in high-risk populations. Methods: We carried out a cross-sectional study of 120 pregnant women (60 with PE and 60 with normotensive controls). Vitamin B12 levels in serum and plasma homocysteine levels were measured. Independent t-tests were made to compare these markers, and correlations between these markers and PE severity were analyzed. Results: The PE group had significantly lower (p<0.01) Vitamin B12 and significantly higher (p<0.01) homocysteine. The existence of positive correlations between homocysteine and blood pressure supports a possible role of Hcy in endothelial dysfunction. Conclusion: PE risks rise in conjunction with Vitamin B12 deficiency and elevated homocysteine, and therefore these biomarkers could prove helpful in predicting PE early. The purpose of these assessments may be to improve outcomes by integrating them into prenatal care.
Description
Keywords
Pre-eclampsia, Vitamin B12, Homocysteine, Endothelial dysfunction, Biomarkers
Citation
Kumar A, Jain J.. Vitamin B12 Deficiency and Hyperhomocysteinemia in Pre-Eclampsia: Assessing Biochemical Markers for Disease Prediction and Therapeutic Potential . SSR Institute of International Journal of Life Sciences. 2024 Dec; 10(6): 6406-6409